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Can Fam Physician
Vol. 53, No. 11, November 2007, pp.1905 - 1911
Copyright © 2007 by The College of Family Physicians of Canada
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Clinical Review

Role of nutrition in preventing cancer

Richard Béliveau, PhD and Denis Gingras, PhD
Researchers in the Laboratoire de Médecine Moléculaire Ste-Justine at the University of Quebec at Montreal and in the Service d’hématologie-oncologie in the Centre de Cancérologie Charles-Bruneau at the Hôpital Ste-Justine in Montreal

Correspondence to: Dr Richard Béliveau, Laboratoire de Médecine Moléculaire, Centre de Recherche de l’Hôpital Ste-Justine, 3175 chemin Côte-Ste-Catherine, Montréal, QC H3T 1C5; telephone 514 345-2366; fax 514 345-2359; e-mail beliveau.richard{at}uqam.ca

OBJECTIVE To summarize the evidence linking dietary habits to the incidence of several types of cancer with special emphasis on the chemoprotective properties of foods that originate from plants.

QUALITY OF EVIDENCE A large body of epidemiologic, animal, and laboratory literature indicates that as many as 30% of all cancer cases are linked to poor dietary habits. The proportion reaches 70% for cancers of the gastrointestinal tract.

MAIN MESSAGE Studies have consistently linked abundant consumption of plant-based food to a substantial reduction in risk of developing various cancers. Laboratory studies show that this chemopreventive effect is related to the high levels of numerous phytochemicals in this food. These phytochemicals interfere with several cellular processes involved in the progression of cancer and also with inflammatory processes that foster development of cancer.

CONCLUSION Dietary factors play an important role in the high incidence of several types of cancer in Canada. Modification of dietary habits to include daily intake of plant-based food containing anticancer and anti-inflammatory phytochemicals thus represents a promising approach to preventing the development of cancer.




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 Cancer Prevention ResearchHome page
S. Lamy, V. Bedard, D. Labbe, H. Sartelet, C. Barthomeuf, D. Gingras, and R. Beliveau
The Dietary Flavones Apigenin and Luteolin Impair Smooth Muscle Cell Migration and VEGF Expression through Inhibition of PDGFR-{beta} Phosphorylation
Cancer Prevention Research, November 1, 2008; 1(6): 452 - 459.
[Abstract] [Full Text] [PDF]


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