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Can Fam Physician
Vol. 53, No. 3, March 2007, pp.409 - 412
Copyright © 2007 by The College of Family Physicians of Canada
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Motherisk Update

Are new agents used to treat rheumatoid arthritis safe to take during pregnancy?

Organization of Teratology Information Specialists (OTIS) study

Christina Chambers, PhD, Gideon Koren, MD FRCPC, Zuhre N. Tutuncu, MD, Diana Johnson, MS and Kenneth L. Jones, MD
QUESTION I have a patient planning pregnancy who has resistant rheumatoid arthritis that will require treatment with some of the "new" medications. Which ones are safe to use during pregnancy, and which ones do we know enough about to tell whether they are safe or not?

ANSWER For most new disease-modifying biologic medications, we have few data on safety. More and more reassuring data are accumulating on azathioprine and cyclosporine. When you treat this patient, you can help in gathering such data by contacting the Organization of Teratology Information Specialists’ Autoimmune Disease in Pregnancy study through Motherisk at 877 311-8972.






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Copyright © 2007 by The College of Family Physicians of Canada.