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Can Fam Physician
Vol. 53, No. 9, September 2007, pp.1439 - 1440
Copyright © 2007 by The College of Family Physicians of Canada
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Motherisk Update

Taking ACE inhibitors during early pregnancy

Is it safe?

Joel G. Ray, MD MSc FRCPC, Marian J. Vermeulen, MHSc and Gideon Koren, MD FRCPC
QUESTION I knew that angiotensin-converting enzyme (ACE) inhibitors were risky to use during late pregnancy because they can cause renal shutdown in the fetus. Recently I heard of a study that claimed first-trimester exposure (when many patients still are unaware of their pregnancies) can also cause major malformations. Is this proven?

ANSWER A recent study did suggest an increased risk of malformations after first-trimester exposure to ACE inhibitors among women treated for hypertension. We believe this study had serious limitations that preclude drawing any conclusions at present.




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