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Can Fam Physician
Vol. 54, No. 11, November 2008, pp.1545 - 1547
Copyright © 2008 by The College of Family Physicians of Canada
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Motherisk Update

Folic acid

The right dose

Gideon Koren, MD FRCPC FACMT, Y. Ingrid Goh and Chagit Klieger, MD
QUESTION The new Motherisk Guidelines suggest 5 mg/d of folic acid. Why was the dose increased? What is the time frame for taking such a dose?

ANSWER Recent data from Ontario reveal that 40% of women of reproductive age still do not achieve therapeutic systemic levels of folate needed to prevent neural tube defects. Compliance is less than optimal among women using prenatal vitamins, rendering many women unprotected against neural tube defects. Taking a higher dose of folate will allow achievement of protective folate levels, even with partial compliance. Five mg of folate should be used daily several months before conception until the end of the first trimester.






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