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Can Fam Physician
Vol. 54, No. 7, July 2008, pp.981 - 983
Copyright © 2008 by The College of Family Physicians of Canada
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Motherisk Update

Effects and treatment of inflammatory bowel disease during pregnancy

Harvinder Brar, PharmD and Adrienne Einarson, RN
QUESTION I have several patients with inflammatory bowel disease (IBD) who are pregnant or planning pregnancies. What information can I give them regarding the possible effects of IBD on pregnancy and the medications used to treat IBD during pregnancy?

ANSWER Women with IBD appear to be at increased risk of giving birth prematurely, having low-birth-weight infants, and having cesarean sections. Neither 5-aminosalicylic acid nor sulfasalazine has been found to increase the rate of major malformations, fetal mortality, or morbidity. There is conflicting evidence regarding the use of corticosteroids and azathioprine and 6-mercaptopurine. There are limited data on the use of infliximab during pregnancy, although no pattern of defects or complications has been reported to date.






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