TY - JOUR T1 - Maternal obesity and risk of neural tube defects. JF - Canadian Family Physician JO - Can Fam Physician SP - 1385 LP - 1385 VL - 47 IS - 7 AU - G Koren Y1 - 2001/07/01 UR - http://www.cfp.ca/content/47/7/1385.abstract N2 - QUESTION: One of my patients is taking olanzapine for schizophrenia. She has gained a lot of weight, which, I understand, often happens with some of the new atypical antipsychotics. Due to her weight gain, she failed to notice she had become pregnant. Is she at risk? ANSWER: Experience with olanzapine is relatively slight, but available prospective data do not show increased teratogenic risk. Adiposity, on the other hand, is associated with increased risk of neural tube defects. Only some of this risk can be reduced by folate supplementation. ER -