RT Journal Article
SR Electronic
T1 Trimethoprim-sulfonamide combination therapy in early pregnancy.
JF Canadian Family Physician
JO Can Fam Physician
FD The College of Family Physicians of Canada
SP 1085
OP 1086
VO 49
IS 9
A1 Anna Sivojelezova
A1 Adrienne Einarson
A1 Samar Shuhaiber
A1 Gideon Koren
A1 Motherisk Team
YR 2003
UL http://www.cfp.ca/content/49/9/1085.abstract
AB QUESTION: One of my patients presented with bacteriuria early in her pregnancy. Urine culture was positive for Escherichia coli. I would like to prescribe a trimethoprim-sulfamethoxazole combination because it worked well for her in the past. What is known about the safety of this medication during early pregnancy? ANSWER: Evidence-based studies report an association between trimethoprim-sulfonamide combinations in early pregnancy and several major malformations, such as neural tube defects and cardiovascular defects. If clinically possible, physicians are advised to use alternative antimicrobial medications for treatment of urinary tract infections during early pregnancy.