RT Journal Article
SR Electronic
T1 Use of proton pump inhibitors during pregnancy and breastfeeding.
JF Canadian Family Physician
JO Can Fam Physician
FD The College of Family Physicians of Canada
SP 853
OP 854
VO 52
IS 7
A1 Alejandro A Nava-Ocampo
A1 Elvia Y Velázquez-Armenta
A1 Jung-Yeol Han
A1 Gideon Koren
YR 2006
UL http://www.cfp.ca/content/52/7/853.abstract
AB QUESTION: A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy. ANSWER: Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.