RT Journal Article SR Electronic T1 Treatment and prevention of herpes labialis JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 1683 OP 1687 VO 54 IS 12 A1 Wim Opstelten A1 Arie Knuistingh Neven A1 Just Eekhof YR 2008 UL http://www.cfp.ca/content/54/12/1683.abstract AB OBJECTIVE To review the evidence regarding the treatment and prevention of herpes labialis. QUALITY OF EVIDENCE The evidence relating to treatment and prevention of herpes labialis is derived from randomized controlled trials (level I evidence). MAIN MESSAGE Treatment with an indifferent cream (zinc oxide or zinc sulfate), an anesthetic cream, or an antiviral cream has a small favourable effect on the duration of symptoms, if applied promptly. This is also the case with oral antiviral medication. If antiviral medicine (cream or oral) is started before exposure to the triggering factor (sunlight), it will provide some protection. Research on sunscreens has shown mixed results: some protection has been reported under experimental conditions that could not be replicated under natural conditions. In the long term, the number of relapses of herpes labialis can be limited with oral antiviral medication. CONCLUSION Only prompt topical or oral therapy will alleviate symptoms of herpes labialis. Both topical and oral treatment can contribute to the prevention of herpes labialis.