RT Journal Article SR Electronic T1 Treatment of herpes zoster JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 373 OP 377 VO 54 IS 3 A1 Wim Opstelten A1 Just Eekhof A1 Arie Knuistingh Neven A1 Theo Verheij YR 2008 UL http://www.cfp.ca/content/54/3/373.abstract AB OBJECTIVE To review the evidence regarding treatment of herpes zoster (HZ) in the short-term, focusing on the prevention of postherpetic neuralgia (PHN). QUALITY OF EVIDENCE The evidence relating to treatment of HZ is derived mainly from randomized controlled trials (level I evidence). MAIN MESSAGE Antiviral drugs might have some effect on the severity of acute pain and on the duration of skin lesions. Corticosteroids also alleviate acute pain. Oral antiviral medication reduces the risk of eye complications in patients with ophthalmic HZ. There is no convincing evidence that antiviral medication reduces the risk of PHN. Some studies, however, have shown that famciclovir and valacyclovir shorten the duration of PHN. The effectiveness of amitriptyline or cutaneous and percutaneous interventions in preventing PHN has not been proven. CONCLUSION Oral antiviral drugs should be prescribed to elderly HZ patients with high risk of PHN. Moreover, these drugs should be prescribed to all patients at the first signs of ophthalmic HZ, irrespective of age or severity of symptoms.