TY - JOUR T1 - Can family physicians help patients initiate basal insulin therapy successfully? JF - Canadian Family Physician JO - Can Fam Physician SP - 550 LP - 558 VL - 54 IS - 4 AU - Stewart Harris AU - Jean-François Yale AU - Ellen Dempsey AU - Hertzel Gerstein Y1 - 2008/04/01 UR - http://www.cfp.ca/content/54/4/550.abstract N2 - OBJECTIVE To determine whether FPs could help patients implement bedtime basal insulin therapy as successfully as diabetes experts could. DESIGN National, multicentre, randomized, open-label trial designed to assess use of bedtime basal insulin therapy compared with use of standard oral-agent therapy for patients with type 2 diabetes being treated by diabetes experts or FPs. SETTING Nineteen endocrinologist or expert sites and 34 family practices. PARTICIPANTS A total of 405 adult patients with hemoglobin A1c(HbA1c) values of 7.5% to 11.0% who were taking 0 to 2 oral agents. INTERVENTION Participants were randomized to receive either basal insulin therapy using glargine self-titrated according to a patient algorithm or conventional therapy with physician-adjusted doses of oral agents for a period of 24 weeks. MAIN OUTCOME MEASURES The primary outcome was time to achieve 2 consecutive HbA1c values ≤ 6.5%. Secondary outcomes were the proportion of subjects who achieved these HbA1c values, a fasting plasma glucose level ≤ 5.5 mmol/L, and 2 consecutive HbA1c values ≤ 7.0%; incidence, rate, and severity of hypoglycemia; daily variations in blood-glucose levels; and participants’ lipid profiles. Post-hoc analysis sought to determine whether patients’ outcomes differed in terms of the above measures depending on whether they had been treated by diabetes experts or FPs. RESULTS A total of 206 patients were randomized to the glargine group, and 199 to the oral agents group. In total, 145 patients were followed by experts and 260 by FPs. Mean reductions in HbA1c and fasting plasma glucose levels and rates of hypoglycemia were comparable in the 2 groups. Patients of both types of physicians achieved significantly greater reductions in fasting plasma glucose with glargine than with oral agents (FPs: −4.14 vs −2.45 mmol/L, P = .0001; experts: −3.47 vs −2.19 mmol/L, P = .0013). Patients of FPs achieved significantly greater reductions in HbA1c levels with glargine than with oral agents (FPs: −1.64 vs −1.26%, P = .0058; experts: −1.41 vs −1.24%, P = .3331). Final mean insulin doses were higher among FPs’ patients than among experts’ patients (41.74 vs 31.66 units, P = .015). Family physicians were more aggressive in their use of insulin, while experts used more oral agents. There were no significant differences in efficacy of treatment. CONCLUSION In most settings, FPs could easily implement the patient-driven bedtime basal insulin protocol used in this study. ER -