RT Journal Article SR Electronic T1 Challenges to diagnosing colorectal cancer during pregnancy JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 881 OP 885 VO 55 IS 9 A1 Mohammad Yaghoobi A1 Gideon Koren A1 Irena Nulman YR 2009 UL http://www.cfp.ca/content/55/9/881.abstract AB QUESTION My patient is 13 weeks pregnant and has experienced rectal bleeding and vomiting. Should I send her for a colonoscopy to rule out colorectal malignancies or should I wait until after delivery? ANSWER The data on colorectal cancer in pregnancy are scarce; however, as the presenting features of colorectal cancer overlap with those of pregnancy itself, there is a risk of development of advanced disease, with poorer prognosis at diagnosis. Therefore, it is strongly recommended that this patient, who is in her second trimester, undergo at least a flexible sigmoidoscopy, which is presumed safe during pregnancy, with or without a liver ultrasound and carcinoembryonic antigen detection based on pretest probability according to her other risk factors.