RT Journal Article
SR Electronic
T1 Taking angiotensin-converting enzyme inhibitors during pregnancy
JF Canadian Family Physician
JO Can Fam Physician
FD The College of Family Physicians of Canada
SP 49
OP 51
VO 58
IS 1
A1 Almundher Al-Maawali
A1 Asnat Walfisch
A1 Gideon Koren
YR 2012
UL http://www.cfp.ca/content/58/1/49.abstract
AB Question One of my 35-year-old pregnant patients has been treated with enalapril for primary hypertension. She learned she was pregnant at 11 weeks’ gestation. I read somewhere that angiotensin-converting enzyme (ACE) inhibitors can cause malformations. What advice do you give to Motherisk callers? Answer Most published studies have failed to show an effect of ACE inhibitors on congenital malformations. A recent systematic review and meta-analysis conducted by Motherisk does not suggest increased fetal risk of malformations. However, ACE inhibitors should be avoided in late pregnancy, as they might cause renal failure and acalvaria in the baby.