PT - JOURNAL ARTICLE AU - Lauren Riggin AU - Gideon Koren TI - Effects of selective serotonin reuptake inhibitors on sperm and male fertility DP - 2015 Jun 01 TA - Canadian Family Physician PG - 529--530 VI - 61 IP - 6 4099 - http://www.cfp.ca/content/61/6/529.short 4100 - http://www.cfp.ca/content/61/6/529.full SO - Can Fam Physician2015 Jun 01; 61 AB - Question Some of my male patients who are taking antidepressants are planning to become fathers. Do selective serotonin reuptake inhibitors (SSRIs) affect sperm, causing either decreased fertility or increased risk of congenital anomalies?Answer There is limited evidence regarding paternal SSRI use before conception and its effects on reproductive outcomes; however, there might be some increased risk of subfertility based on animal studies and sperm-quality studies. There are insufficient data at this time to change prescribing practices of SSRIs in men who are hoping to become fathers.