RT Journal Article SR Electronic T1 Omega-3 for nonalcoholic fatty liver disease in children JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 34 OP 38 VO 65 IS 1 A1 Paul Clerc A1 Marialena Mouzaki A1 Ran D. Goldman YR 2019 UL http://www.cfp.ca/content/65/1/34.abstract AB Question An overweight 12-year-old male patient with nonalcoholic fatty liver disease has had little improvement in liver steatosis or triglyceride levels over the past 2 years. Is omega-3 supplementation useful in managing his condition?Answer Nonalcoholic fatty liver disease in children is prevalent in the Canadian population and can lead to liver fibrosis, cirrhosis, transplant, and reduced life expectancy. There is no recommended pharmacologic treatment of nonalcoholic fatty liver disease. Omega-3 fatty acids are associated with small improvements in liver steatosis and triglyceride concentrations. There are conflicting results with regard to liver function test results and insulin resistance, and while there might be histologic improvement revealed on biopsy, there is little evidence that fibrosis is improved. In children who have struggled to be consistent with the changes needed in their diet, particularly those with elevated triglyceride levels, there might be a role for omega-3 supplementation while continuing to focus on the mainstays of treatment (diet and physical activity); however, further research is still needed.