Table 5

Therapeutic approaches proven effective in patients with nonalcoholic fatty liver disease or in animal models of nonalcoholic fatty liver

Gradual weight reduction

  • Caloric restriction

  • Physical activity

  • Bariatric surgery

Insulin sensitizers

  • Metformin

  • Thiazolidinediones (rosiglitazone, pioglitazone)

Lipid-lowering agents

  • Fibrates (gemfibrozil)

  • Fish oil

Antioxidants

  • Vitamin E

  • N-acetylcysteine

  • Betaine

  • Adapted from Portincasa et al.46