Factors that suggest biochemical recurrence (BCR) represents local vs distant disease after primary treatment with surgery or radiotherapy
| FACTOR | LOCAL RECURRENCE | DISTANT RECURRENCE |
|---|---|---|
| Initial pathology | Gleason score < 7 | Gleason score ≥ 7 |
| Positive surgical margin | Extra-prostatic involvement | |
| No nodal involvement | Nodal involvement | |
| Time to BCR after treatment | > 1–2 y | < 1 y |
| Pretreatment PSA level | < 10 ng/mL | > 10 ng/mL |
| PSADT | > 12 mo | < 6–12 mo |
PSA—prostate-specific antigen, PSADT— prostate-specific antigen doubling time.