PROPOSED EVOLUTIONARY EXPLANATION | DISORDERS |
---|---|
Heterozygote advantage | Sickle cell disease7 |
Cystic fibrosis8 | |
Phenylketonuria9 | |
Antagonistic pleiotropy; adaptation to ancestral environment | Hemochromatosis10,11 |
Antagonistic pleiotropy | Gout12 |
Atherosclerosis13 | |
Prostatic hypertrophy14 | |
Alzheimer disease15 | |
Adaptation to ancestral environment | Obesity16 |
Type II diabetes17,18 | |
Essential hypertension14 | |
Drug abuse19 | |
Female reproductive cancers20 |