Association between achieved DBP and outcomes in INVEST reanalysis
| ACHIEVED DBP, % | |||||
|---|---|---|---|---|---|
| EFFICACY OUTCOMES | < 70 mm Hg | 70-90 mm Hg | ARI, % | RR, % | NNH (95% CI) FOR 2.7 Y |
| All-cause death, nonfatal MI, nonfatal stroke | 18.4 | 8.6 | 9.9 | 2.1 | 10 (9-12) |
| Fatal and nonfatal MI | 6.5 | 3.4 | 3.1 | 1.9 | 32 (24-48) |
| Fatal and nonfatal stroke | 2.2 | 1.4 | 0.8 | 1.6 | 126 (71-542) |
Results calculated from data in Messerli et al23; NNH calculated using the Dalhousie University Katie Clinical Significance Calculator.17
ARI—absolute risk reduction, DBP—diastolic blood pressure, MI—myocardial infarction, NNH—number needed to harm, RR—relative risk.