Comparing level and quality of best evidence for lipid markers in making treatment decisions
| LIPID PARAMETER | GRADE* | INTERPRETATION | EVIDENCE TYPE |
|---|---|---|---|
| Metabolic syndrome | 1C | Strong recommendation Low-quality evidence | Meta-analysis of prospective cohort studies16 |
| TC/HDL ratio | 1B | Strong recommendation Moderate-quality evidence | 1 RCT56 Meta-analysis of prospective observational studies; post hoc data analysis57 |
| Non-HDL cholesterol | 1B | Strong recommendation Moderate-quality evidence | Meta-analysis of RCT lipid-lowering drug studies; post hoc data analysis58 Meta-analysis of RCT statin trials53 |
| Apo B | 1B | Strong recommendation Moderate-quality evidence | 2 RCTs,56,59 1 RCT with subgroup analysis,60 1 RCT with post hoc analysis61 Meta-analysis of observational studies62 |
Apo B—apolipoprotein B, HDL—high-density lipoprotein, RCT—randomized controlled trial, TC—total cholesterol.
↵* GRADE system for rating quality of evidence and strength of recommendations.63