Simon Broome Register |
DNA mutation consistent with FH (category A) Lipid panel (category B): in adults, a TC level of > 7.5 mmol/L or LDL level of > 4.9 mmol/L; in pediatric patients, TC level of > 6.7 mmol/L or LDL level of > 4.0 mmol/L Tendinous xanthoma in the patient or any first- or second-degree relative (category C) Family history of myocardial infarction (category D): age < 60 y in first-degree relative; age < 50 y in second-degree relative Family history of a TC level of > 7.5 mmol/L in a first- or second- degree relative (category E)
| Definite FH:
Category A Category B + category C
Probable FH:
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Dutch Lipid Network | History and physical characteristics:
Personal history of CAD, or first-degree relative < 18 y with LDL values > 95th percentile or with tendinous xanthoma or arcus senilis (2 points) Personal history of premature cerebral or peripheral vascular disease or first-degree adult relative with premature CAD or LDL values > 95th percentile (1 point) Tendinous xanthoma (6 points) Arcus senilis at age < 45 y (4 points)
LDL levels:
Genetic testing:
| Definite FH:
Probable FH:
Possible FH:
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