Total combined spending
| DRUG CLASS | TOTAL CURRENT ANNUAL SPENDING, $ | RATIONAL ANNUAL SPENDING, $ | SAVINGS, $ |
|---|---|---|---|
| Statins | 588 069 179 | 553 719 680 | 34 349 499 |
| Proton pump inhibitors | 537 347 849 | 371 241 953 | 166 105 896 |
| Angiotensin-converting enzyme inhibitors | 350 592 520 | 200 291 793 | 150 300 727 |
| Selective serotonin reuptake inhibitors | 494 813 443 | 324 891 006 | 169 922 437 |
| Total | 1 970 822 991 | 1 450 144 432 | 520 678 559 |