Table 3.

Major bleeding and thromboembolic events

TIMING OF INR RESULTAGE, YSEXINDICATION FOR ANTICOAGULATIONTARGET INRCARE SOUGHTTIME FROM CRITICAL INR RESULT TO EVENTEVENTINR CLOSEST TO EVENTOUTCOME
During clinic hours75MaleVTE2.0–3.0Hospitalized29 dDVT1.5Nonfatal
26FemaleVTE2.0–3.0Emergency departmentSame dayGI bleeding5.6Nonfatal
45MaleSuperior mesenteric vein thrombosis2.2–3.2Hospitalized21 dGI bleeding1.6Nonfatal
51FemaleMechanical mitral valve2.5–3.5Emergency department18 dBleeding, large bruises to arms and legs2.8Nonfatal
74MaleAtrial fibrillation2.0–3.0Hospitalized1 dGI bleeding10.0Nonfatal
After hours85FemaleAtrial fibrillation2.0–3.0Hospitalized15 dStroke1.4Fatal
27MaleLV dysfunction2.0–3.0Emergency department1 dGenitourinary bleeding9.1Nonfatal
58FemaleAtrial fibrillation2.0–3.0Hospitalized16 dGI bleeding2.0Nonfatal
67MaleDVT, portal vein2.5–3.0HospitalizedSame dayBleeding, fell and bruised ribs7.0Nonfatal
40MaleVTE2.0–3.0Emergency department2 dGenitourinary bleeding1.8Nonfatal
80MaleAtrial fibrillation2.0–3.0Hospitalized2 dGI bleeding5.3Nonfatal
66MaleVTE2.0–3.0Hospitalized30 dRetroperitoneal bleeding1.5Nonfatal
  • DVT—deep-vein thrombosis, GI—gastrointestinal, INR—international normalized ratio, LV—left ventricular, VTE—venous thromboembolism.