Abstract
Summary
Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical fractures. Incident fractures had a negative impact on HUI scores over time.
Introduction
This study examined change in health-related quality of life (HRQL) in those with and without incident clinical fractures as measured by the HUI.
Methods
The study cohort was 4,820 women and 1,783 men (50 years and older) from the CaMos. The HUI was administered at baseline and year 5. Participants were sub-divided into incident fracture groups (hip, rib, spine, forearm, pelvis, other) and were compared with those without these fractures. The effects of both time and fracture type on HUI scores were examined in multivariable regression analyses.
Results
Men and women with hip fractures, compared to those without, had lower HUI measures that ranged from −0.05 to −0.25. Both women and men with spine fractures had significant deficits on the pain attributes (−0.07 to −0.12). In women, self-care (−0.06), mobility and ambulation (−0.05) were also negatively impacted. Women with rib fractures had deficits similar to women with spine fractures, and these effects persisted over time. In men, rib fractures did not significantly affect HUI scores. Pelvic and forearm fractures did not substantially influence HUI scores.
Conclusion
The HUI was a sensitive measure of HRQL change over time. These results will inform economic analyses evaluating osteoporosis therapies.
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Conflicts of interest
Alexandra Papaioannou, MD, FRCPC, MSc
Consulting and Advisory Role: Amgen, Eli Lilly, Merck Frosst, Novartis, Proctor and Gamble, sanofi-aventis, Servier
Clinical Trials: Amgen, Eli Lilly, Merck, Novartis, Proctor and Gamble, sanofi-aventis
Jacques P. Brown, MD, FRCPC has received honoraria for lecturing, consultancies, grants and research support for clinical trials: Abbott, Alpharx, Amgen, Arthrolab, sanofi-aventis Canada, Boehringer Ingelheim/Roche, Bristol-Myers Squibb, Celltech, Eli Lilly Canada, Genizon, Glaxosmithkline, Merck Frosst, Nicox, Novartis, NPS Pharma, Pfizer, Proctor and Gamble, Quintiles, Rhône-Poulenc Rorer, Servier, Wyeth, Zelos
Robert G. Josse, MB, FRCPC
Advisory boards, honoraria, research grants: Lilly, Proctor and Gamble/sanofi-aventis, Merck, Novartis, Servier, GlaxoSmithKline, Amgen, Wyeth
Emmanuel Papadimitropoulos, PhD is an employee of Eli Lilly and Company in the Research and Development division.
Stephanie M Kaiser, MD, FRCPC
Advisory Boards: Amgen, Eli Lilly, Novartis, Wyeth-Ayerst, Servier
Speaker for: Amgen, Eli Lilly, Novartis, Merck, Procter and Gamble/sanofi-aventis, AstraZeneca, Servier
David Goltzman, MD, FRCPC
Consulting Role: Lilly, Novartis, sanofi-aventis, Proctor and Gamble, Servier
Wojciech P. Olszynski, MD, FRCPC
Consulting Role: Abbott Laboratories, Limited; Merck Frosst Canada Ltd.; Amgen Canada Inc.; Novartis Pharmaceutical Canada Inc.; Aventis Pharma Inc.; Pfizer Canada Inc.; Boehringer Ingelheim (Canada) Ltd.; Procter and Gamble Pharmaceutical Canada, Inc.; Eli Lilly Canada Inc.; Sanofi-Synthelabo Canada Inc.; Genzyme Canada Inc.; Schering Canada Inc.; GlaxoSmithKline Inc.; Servier Canada Inc.; Hoffmann-LaRoche Limited; Solvay Pharma Inc.; Janssen-Ortho Inc./Ortho-Biotech; Wyeth Canada
Jonathan D. Adachi, MD, FRCPC
Consulting Role: Amgen; Astra Zeneca, Eli Lilly; GlaxoSmithKline; Merck Frosst; Novartis; Proctor and Gamble; Roche; sanofi-aventis; Servier
Clinical Trials: Eli Lilly; GlaxoSmithKline; Merck; Novartis; Pfizer; Proctor and Gamble; sanofi-aventis; Servier; Wyeth-Ayerst
Courtney C. Kennedy, MSc; George Ioannidis, MSc; Anna M. Sawka MD, FRCPC, PhD; Wilma M. Hopman, MSc; Laura Pickard MSc; Tassos Anastassiades, MD; Alan Tenenhouse, MD; Jerilynn C. Prior MD: No competing interests to declare.
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Papaioannou, A., Kennedy, C.C., Ioannidis, G. et al. The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study. Osteoporos Int 20, 703–714 (2009). https://doi.org/10.1007/s00198-008-0743-7
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DOI: https://doi.org/10.1007/s00198-008-0743-7