Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control study☆
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Environmental and occupational risk factors for myelodysplastic syndrome
2023, Bulletin du CancerChallenging the concept of de novo acute myeloid leukemia: Environmental and occupational leukemogens hiding in our midst
2021, Blood ReviewsCitation Excerpt :One population-based, matched case-control study reported a matched OR (mOR) of 1.76 (95% CI: 1.37-2.26); risk was specifically increased among those employed in “crop production” (mOR = 1.78, 95% CI: 1.35-2.33) [102]. This increased risk has been attributed to chronic exposure to chemicals routinely used in agriculture, such as pesticides, including insecticides, herbicides, fungicides, and rodenticides [103]. The heterogeneous chemical structures, physiochemical properties, and mechanisms of action of pesticides present a challenge for exposure assessment and epidemiological analyses.
Occupational and environmental etiology of MDS
2013, Best Practice and Research: Clinical HaematologyCitation Excerpt :Several small to medium sized case control studies of occupational and environmental exposures are reported for AML [16–19]. Although no consistent exposures are identified across all studies, various studies highlight pesticide exposure as a risk factor [16,17,20], some implicate solvent exposure [18], and others tobacco smoke exposure [19] (Tables 1 and 2). MDS cases are reported in cohorts of people exposed to radiation, for treatment of diseases such as ankylosing spondylitis [21], or following exposure to the A-bomb in Hiroshima and Nagasaki [22].
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
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2010, Leukemia ResearchChronic myelogenous leukemia and benzene exposure: A systematic review and meta-analysis of the case-control literature
2009, Chemico-Biological Interactions
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This work was supported by Grant No. 90-1063 (to P.V.) from the EEC-Europe Against Cancer Programme and a grant from Associazione Italiana per le Ricerche sul Cancro.