Elsevier

Toxicology Letters

Volume 1, Issue 1, July 1977, Pages 21-26
Toxicology Letters

Arthropathy induced by antibacterial fused N-alkyl-4-pyridone-3-carboxylic acids

https://doi.org/10.1016/0378-4274(77)90016-9Get rights and content

Abstract

The antibacterial agents, nalidixic, oxolinic and pipemidic acids, induced lameness, associated with exudation of synovial fluid and blistering and ulcerative erosion of articular cartilage, in the joints of the limbs of immature, but not mature, dogs when administered daily, for periods of 1–15 days, at dose rates of 200–1000 mg/kg. Clinical recovery usually occurred within 14–21 days, even with continued medication, but the lesions had not resolved in animals autopsied up to 87 days after withdrawal of the drug. The lesions were also present at autopsy m immature dogs which had received pipemidic acid daily for 6 months, in spite of the fact that the animals had been clinically normal for all except the first 4 or 5 weeks of the study.

Microscopical examination showed that fissuring occurred in the intermediate, germinal, zone of cartilage. Hypertrophy of chondrocytes was a common finding, with some large cell nests and multinucleate cells. In a few cases, some disorganisation of epiphyseal plates was seen.

References (1)

  • R.R. Bailey et al.

    Nalidixic acid arthralgia

    Can. Med. Ass. J.

    (1972)

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