Original contributionBuffered lidocaine as a local anesthetic: An investigation of shelf life
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Cited by (66)
Laceration repair
2017, Urgent Care Medicine SecretsThe stability and microbial contamination of bupivacaine, lidocaine and mepivacaine used for lameness diagnostics in horses
2016, Veterinary JournalCitation Excerpt :LAs are sensitive to alkalisation, and therefore, the manufacturer adjusts the pH of lidocaine to between 5 and 7, mepivacaine to 5.5–6.5, and bupivacaine to 4–6.5. In human medicine, lidocaine is often buffered (pH is raised to 7.2–7.4) to reduce pain at injection sites (Christoph et al., 1988; Bartfield et al., 1992). Such buffering has been shown to cause substantial degradation of lidocaine over time (Larson et al., 1991; Bartfield et al., 1992).
Does Combined Use of the J-tip® and Buzzy® Device Decrease the Pain of Venipuncture in a Pediatric Population?
2015, Journal of Pediatric NursingCitation Excerpt :A recent study looking at phlebotomy with use of the Buzzy® indicated that 80% of children would like it to be used again and 81% of phlebotomists felt that it facilitated the procedure, but it was not coupled with the J-tip® in this trial (Whelan, Kunselman, Thomas, et al., 2014). Of note, in this paper, we used unbuffered lidocaine in the J-tip®, as storage of buffered lidocaine is discouraged at our institution due to concerns related to the stability of opened buffered lidocaine (Bartfield, Homer, Ford, et al., 1992). This may have impacted the results, and pain difference associated with buffering of lidocaine in the J-tip® has not been widely studied.
Acute pain management in dermatology Risk assessment and treatment
2015, Journal of the American Academy of DermatologyCitation Excerpt :A Cochrane metaanalysis has shown significantly better pain outcomes with buffered lidocaine compared to plain lidocaine infiltration for a variety of minimally invasive procedures. However, buffered lidocaine must be used within 1 week.53 Zeiac et al54 reported that a diluted mixture of lidocaine 1% with epinephrine in bacteriostatic sodium chloride 0.9% in a 1:10 ratio is also effective in managing pain with infiltrative anesthesia.
Effect of sodium bicarbonate-buffered lidocaine on the success of inferior alveolar nerve block for teeth with symptomatic irreversible pulpitis: A prospective, randomized double-blind study
2015, Journal of EndodonticsCitation Excerpt :Therefore, the volume of LA was the same in the 2 groups. Although buffered lidocaine remains effective for as long as 1 week after preparation (24), the buffered lidocaine formulations were prepared immediately before the injections. The success of the IAN block was evaluated by measuring the pain level during endodontic access and initial instrumentation using the HP-VAS, and further tests with an electric pulp tester were eliminated in this study.
Infiltration and Nerve Block Anesthesia
2012, Wounds and Lacerations: Emergency Care and Closure