Original articleSleep-Disordered Breathing and the Metabolic Syndrome in Overweight and Obese Children and Adolescents
Section snippets
Methods
Consecutive subjects aged 6 to 17 years who were overweight or obese were recruited between January 2001 and September 2006 at the Pediatric Obesity Clinic of the Antwerp University Hospital. Children were excluded when they had any chronic medical condition, any genetic, neuromuscular, or craniofacial syndromes, or were receiving medications that are known to affect glucose homeostasis or serum lipid levels. Patients were classified as prepubertal or pubertal on the basis of a combination of
Results
A total of 104 subjects were studied; 44% were boys, and 58% were prepubertal, with a mean age of 11.1 ± 2.6 years (range, 6.1-16.7 years). The mean BMI z-score was 2.3 ± 0.5 (range, 1.3-3.8); 32 subjects (31%) were overweight, and 72 subjects (69%) were obese. No subject had diabetes mellitus.
The MS was present in 34 of 93 subjects (37%). In 11 subjects, the diagnosis of the MS could not be made, because of laboratory errors. Subjects with the MS had a higher waist circumference (88.5 ± 12.6
Discussion
The features comprising the metabolic or insulin-resistance syndrome are hyperinsulinemia, dyslipidemia, central obesity, and hypertension.27 Several reports have documented the prevalence of the MS in pediatric obesity.28, 29 Furthermore, high fasting insulin levels and increased BMI during childhood are strong predictors of the MS in adulthood,30 and children with insulin resistance have an increased risk of future cardiovascular morbidity and mortality.31 By aggravating the obesity-related
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2017, Physiology and BehaviorCitation Excerpt :Since SDB and obesity independently favor cardiometabolic comorbidities, it seems relevant to investigate whether SDB is an additional risk factor for metabolic disturbances in obese pediatric population. Some authors have observed an interaction between SDB and metabolic abnormalities in overweight and obese children and adolescents [11]. In their analysis, Redline and collaborators found that 70% of adolescents with sleep disturbances are overweight, with about 59% of them also presenting MS [12].