Clinical-liver, pancreas, and biliary tractAcute Hepatitis A Infection in Pregnancy Is Associated With High Rates of Gestational Complications and Preterm Labor
Section snippets
Patients
We reviewed the computerized diagnoses of all pregnant patients who were admitted to Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem, Israel, between the years 1980 and 2005. The participating hospital serves as primary, secondary, and tertiary medical care facility. Included were patients who presented with HAV-induced acute hepatitis during pregnancy, diagnosed by positive anti-HAV immunoglobulin (Ig)M serology and absence of other etiologies for acute liver injury.
Baseline Characteristics of the Study Population
At the Hadassah-Hebrew University Medical Center, Mount Scopus Campus, 79,458 deliveries were carried out during 1980–2005. Thirty-four cases of acute hepatitis were recognized among hospitalized pregnant individuals. Among these, 13 cases of acute hepatitis caused by HAV infection were identified by a combination of acute elevation of serum aminotransferase activity, positive IgM anti-HAV serology, and absence of other causes of acute hepatitis. The 21 cases of non-HAV acute hepatitis were
Discussion
This retrospective study, focusing on the clinical characteristics of acute HAV hepatitis during pregnancy, reveals that HAV infection during second and third trimester of pregnancy is associated with a high rate of gestational complications and preterm labor. Furthermore, in our study, a causal relationship between HAV infection and preterm labor is suggested by the temporal association between the 2 events. Considering the relatively mild nature of maternal disease noticed in our subjects,
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