Elsevier

Genetics in Medicine

Volume 12, Issue 6, June 2010, Pages 370-375
Genetics in Medicine

Article
Validation of My Family Health Portrait for six common heritable conditions

https://doi.org/10.1097/GIM.0b013e3181e15bd5Get rights and content
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Abstract

Purpose

To assess the ability of My Family Health Portrait to accurately collect family history for six common heritable disorders.

Background

Family history is useful to assess disease risk but is not widely used. We compared the pedigree from My Family Health Portrait, an online tool for collection of family history, to a pedigree supplemented by a genetics professional.

Methods

One hundred fifty volunteers collected their family histories using My Family Health Portrait. A genetic counselor interviewed the volunteers to validate the entries and add diagnoses, as needed. The content and the affection assignments of the pedigrees were compared. The pedigrees were entered into Family HealthwareTM to assess risks for the diseases.

Results

The sensitivity of My Family Health Portrait varied among the six diseases (67–100%) compared to the supplemented pedigree. The specificities ranged from 92 to 100%. When the pedigrees were used to generate risk scores, My Family Health Portrait yielded identical risks to the supplemented pedigree for 94–99% of the volunteers for diabetes and colon, breast, and ovarian cancer. The agreement was lower for coronary artery disease (68%) and stroke (83%).

Conclusions

These data support the validity of My Family Health Portrait pedigrees for four common conditions—diabetes and colon, breast, and ovarian cancer. The tool performed less well for coronary artery disease and stroke. We recommend that the tool be improved to better capture information for these two common conditions.

Keywords

My Family Health Portrait
common disease
family history
risk assessment
pedigree

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