The acute wound presents a spectrum of issues that prevent its ultimate closure. These issues include host factors, etiology, anatomic location, timing, and surgical techniques to achieve successful wound closure. Basic surgical principles need to be followed to obtain stable, long-term coverage, ultimately restoring form and function. Recent advances in dressings, debridement techniques, and surgical repertoire allow the modern plastic surgeon to address any wound of any complexity. This article discusses these principles that can be applied to any wound.