The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective

Hongyan Xia; Niklas Wahlberg; Sándor Belák; X J Meng; Lihong Liu

doi:10.1007/s00705-010-0818-6

The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective

Arch Virol. 2011 Jan;156(1):121-4. doi: 10.1007/s00705-010-0818-6. Epub 2010 Oct 7.

Authors

Hongyan Xia¹, Niklas Wahlberg, Sándor Belák, X J Meng, Lihong Liu

Affiliation

¹ Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

PMID: 20927637
DOI: 10.1007/s00705-010-0818-6

Abstract

To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Communicable Diseases, Emerging
Evolution, Molecular
Genotype*
Hepatitis E / epidemiology
Hepatitis E / veterinary*
Hepatitis E / virology
Hepatitis E virus / genetics*
Humans
Molecular Epidemiology
Phylogeny*
Species Specificity