Abstract
Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.
Trial registration:
ClinicalTrials.gov NCT00879996.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Administration, Sublingual
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Analgesics, Opioid / administration & dosage
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Analgesics, Opioid / therapeutic use*
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Analgesics, Opioid / urine
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Analysis of Variance
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Buprenorphine / administration & dosage
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Buprenorphine / therapeutic use*
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Chronic Pain / complications
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Chronic Pain / drug therapy*
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Drug Combinations
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Female
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Humans
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Male
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Methadone / administration & dosage
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Methadone / therapeutic use*
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Middle Aged
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Naloxone / administration & dosage
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Naloxone / therapeutic use
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Opioid-Related Disorders / complications
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Opioid-Related Disorders / drug therapy*
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Opioid-Related Disorders / urine
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Prescription Drug Misuse
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Severity of Illness Index
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Substance Abuse Detection*
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Treatment Outcome
Substances
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Analgesics, Opioid
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Drug Combinations
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Naloxone
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Buprenorphine
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Methadone
Associated data
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ClinicalTrials.gov/NCT00879996