Coronary artery disease (CAD) remains a major public health problem in the world. Acute coronary syndromes (ACS) mainly affect patients with cardiovascular risk factors. We report the case of an exercise-induced ACS in a 24-year-old soccer player without any classic cardiovascular risk factor, but with a history of massive cannabis addiction. Coronary angiography showed complete occlusion of the proximal right coronary artery and intravascular ultrasound revealed an atherosclerotic plaque disruption. Thromboaspiration and antithrombotic treatment were successful and coronary stenting was not performed. The respective roles of cannabis toxicity and physical activity as triggers for ACS in young people are discussed.