Opioid-induced itching: morphine sulfate and hydromorphone hydrochloride

J Pain Symptom Manage. 1999 Jan;17(1):70-2. doi: 10.1016/s0885-3924(98)00115-8.

Abstract

We describe a case of severe morphine-induced itch unrelieved by antihistamines, which responded to a change to hydromorphone. The possible mechanisms of opioid-induced itch are briefly discussed. It is unclear if it is due to histamine release, an opioid-receptor mediated effect, or idiosyncratic drug reaction.

Publication types

  • Case Reports

MeSH terms

  • Analgesics, Opioid / adverse effects*
  • Analgesics, Opioid / therapeutic use
  • Humans
  • Hydromorphone / adverse effects*
  • Hydromorphone / therapeutic use
  • Male
  • Middle Aged
  • Morphine / adverse effects*
  • Morphine / therapeutic use
  • Pain, Intractable / complications
  • Pain, Intractable / drug therapy
  • Palliative Care
  • Pruritus / chemically induced*

Substances

  • Analgesics, Opioid
  • Morphine
  • Hydromorphone