Drug-induced liver injury (DILI) has become a leading cause of severe liver disease in
Western countries and therefore poses a major clinical and regulatory challenge. Whereas …

Although the biochemical steps linking insulin resistance with the metabolic syndrome have
not been completely clarified, mounting experimental and clinical evidence indicate …

Mounting clinical and experimental evidence indicates that free radicals play important roles
in many physiological and pathological conditions. The wider application of free radical …

Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to
knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic …

Although evidence suggests the link between chronic inflammation and oxidative stress as
the main mechanism responsible for endothelial dysfunction and cardiovascular …

purpose. Oxidative damage to lens proteins is a major factor leading to cataract formation. It
is of pathogenic importance to determine a threshold of protein oxidation over which …

Mitochondrial dysfunction and oxidative stress play a central role in the pathophysiology of
nonalcoholic fatty liver disease (NAFLD). This study aimed to elucidate the mechanism(s) …

Hepatic steatosis is associated with mitochondrial oxidative alterations. This study aimed to
characterize in a choline-deficient model of rat fatty liver whether this oxidative imbalance is …

Retinoic acid (RA) is a potent teratogen in all vertebrates when tight homeostatic controls on
its endogenous dose, location, or timing are perturbed during early embryogenesis. STRA6 …

The understanding of the involvement of mitochondrial oxidative phosphorylation (OXPHOS)
in the aging process has often been biased by the different methodological approaches as …