Membrane excitability is a critical regulatory step in skeletal muscle contraction and is modulated
by local ionic concentrations, conductances, ion transporter activities, temperature, and …

Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear
magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal …

Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

TAXOL 1–4 , a substance originally isolated from the Pacific yew tree (Taxus brevifolia)
more than two decades ago, has recently been approved for the clinical treatment of cancer …

Background The success of the CRISPR/Cas9 genome editing technique depends on the
choice of the guide RNA sequence, which is facilitated by various websites. Despite the …

The ability of nuclear receptors (NRs) to activate transcription of target genes requires the
binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the …

The 2.0-Å crystal structure of the ligand-binding domain (LBD) of the human retinoic acid
receptor (RAR)-γ bound to all-trans retinoic acid reveals the ligand-binding interactions and …

… the results) nearest functional neighbors j in the focal assemblage and the … j is the number
of occurrences of neighbor species j and d ij is the functional distance between species i and j. …

Objectives : We evaluated the prognostic value of myocardial flow reserve (MFR) using
rubidium-82 ( 82 Rb) positron emission tomography (PET) in patients assessed for ischemia. …

Fe and Mn porphyrins alone are almost unable to catalyze cyclooctene epoxidation or
cyclooctane hydroxylation by H202. In the presence of imidazole, Mn (III) porphyrins, and …