Mammalian mitochondrial DNA (mtDNA) is present at high copy number (10 3 -10 4 copies)
in virtually all cells of the body. the mitochondrial genome shows strict maternal inheritance …

The mammalian mitochondrial genome (mtDNA) is a small double-stranded DNA molecule
that is exclusively transmitted down the maternal line. Pathogenic mtDNA mutations are …

… Nicholas Howell is an MD–PhD candidate at the University of Toronto, having completed the
… Dr Howell holds an undergraduate degree (psychology) and master's degree (Institute of …

The Human Genome Project, from one perspective, began in 1981 with the publication 1 of
the complete sequence of human mitochondrial DNA (mtDNA). The Cambridge reference …

… Howell, N. 1984 Perspectives and prospects for understanding the effects of population on
… Howell, N. 1986 Feedbacks and buffers in relation to scarcity and abundance: Studies of …

Background COVID-19 vaccine supply shortages are causing concerns about compromised
immunity in some countries as the interval between the first and second dose becomes …

We performed the first population-based clinical and molecular genetic study of Leber
hereditary optic neuropathy (LHON) in a population of 2,173,800 individuals in the North East of …

Biochemical and molecular genetic evidence is presented that in six independent pedigrees
the development of Leber hereditary optic neuropathy (LHON) is due to the same primary …

Many patients with inherited mitochondrial encephalopathies have one of two pathogenic
mutations of mitochondrial DNA (mtDNA): A3243G or A8344G. Individuals who harbour these …

… ), T n p 14 n p 33 n p 47 ( … ), and X n p 46 n p 42 n p 8 n p 8 ( ), as well as 50 H
haplotypes that were ran- n p 11 domly selected from a total of 226. For this network, …