User profiles for T. Laughlin

Thomas "Tom" G. Laughlin

Altos Labs
Verified email at altoslabs.com
Cited by 462

Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone

TW Vandera, T Laughlin, JM Lashbrook, ML Nichols… - Pain, 1996 - Elsevier
Neuropathic pain states are accompanied by increased sensitivity to both noxious and non-noxious
sensory stimuli, characterized as hyperalgesia and allodynia, respectively. In animal …

Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes

LA Lyons, TF Laughlin, NG Copeland, NA Jenkins… - Nature …, 1997 - nature.com
Precise comparisons of mammalian gene maps require common anchor loci as landmarks
for conserved chromosomal segments. Using a computer script that automates DNA …

[HTML][HTML] Recent advances on the structure and function of NDH-1: The complex I of oxygenic photosynthesis

TG Laughlin, DF Savage, KM Davies - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Photosynthetic NADH dehydrogenase-like complex type-1 (aka, NDH, NDH-1, or NDH-1L)
is a multi-subunit, membrane-bound oxidoreductase related to the respiratory complex I. …

[HTML][HTML] Architecture and self-assembly of the jumbo bacteriophage nuclear shell

TG Laughlin, A Deep, AM Prichard, C Seitz, Y Gu… - Nature, 2022 - nature.com
Bacteria encode myriad defences that target the genomes of infecting bacteriophage, including
restriction–modification and CRISPR–Cas systems 1 . In response, one family of large …

Structure of the complex I-like molecule NDH of oxygenic photosynthesis

TG Laughlin, AN Bayne, JF Trempe, DF Savage… - Nature, 2019 - nature.com
Cyclic electron flow around photosystem I (PSI) is a mechanism by which photosynthetic
organisms balance the levels of ATP and NADPH necessary for efficient photosynthesis 1 , 2 . …

Identification of a carbonic anhydrase–Rubisco complex within the alpha-carboxysome

C Blikstad, EJ Dugan, TG Laughlin… - Proceedings of the …, 2023 - National Acad Sciences
Carboxysomes are proteinaceous organelles that encapsulate key enzymes of CO 2 fixation—Rubisco
and carbonic anhydrase—and are the centerpiece of the bacterial CO 2 …

Iron (III) tosylate catalyzed synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones/thiones via the Biginelli reaction

JT Starcevich, TJ Laughlin, RS Mohan - Tetrahedron Letters, 2013 - Elsevier
The synthesis of dihydropyrimidinones and dihydropyrimidine thiones has attracted interest
due to their biological activities. A common method for their synthesis is the Biginelli reaction…

[HTML][HTML] Rubisco forms a lattice inside alpha-carboxysomes

…, C Blikstad, DR Lovejoy, TG Laughlin… - Nature …, 2022 - nature.com
Despite the importance of microcompartments in prokaryotic biology and bioengineering,
structural heterogeneity has prevented a complete understanding of their architecture, …

[HTML][HTML] Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

A Shams, SA Higgins, C Fellmann, TG Laughlin… - Nature …, 2021 - nature.com
Proteins evolve through the modular rearrangement of elements known as domains. Extant,
multidomain proteins are hypothesized to be the result of domain accretion, but there has …

[PDF][PDF] Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

…, TG Laughlin, A Lee, KP Thomas, AE Sy, T Spencer… - Cell reports, 2023 - cell.com
We recently discovered that some bacteriophages establish a nucleus-like replication
compartment (phage nucleus), but the core genes that define nucleus-based phage replication …