User profiles for T. Laughlin
Thomas "Tom" G. LaughlinAltos Labs Verified email at altoslabs.com Cited by 462 |
Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone
TW Vandera, T Laughlin, JM Lashbrook, ML Nichols… - Pain, 1996 - Elsevier
Neuropathic pain states are accompanied by increased sensitivity to both noxious and non-noxious
sensory stimuli, characterized as hyperalgesia and allodynia, respectively. In animal …
sensory stimuli, characterized as hyperalgesia and allodynia, respectively. In animal …
Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes
LA Lyons, TF Laughlin, NG Copeland, NA Jenkins… - Nature …, 1997 - nature.com
Precise comparisons of mammalian gene maps require common anchor loci as landmarks
for conserved chromosomal segments. Using a computer script that automates DNA …
for conserved chromosomal segments. Using a computer script that automates DNA …
[HTML][HTML] Recent advances on the structure and function of NDH-1: The complex I of oxygenic photosynthesis
TG Laughlin, DF Savage, KM Davies - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Photosynthetic NADH dehydrogenase-like complex type-1 (aka, NDH, NDH-1, or NDH-1L)
is a multi-subunit, membrane-bound oxidoreductase related to the respiratory complex I. …
is a multi-subunit, membrane-bound oxidoreductase related to the respiratory complex I. …
[HTML][HTML] Architecture and self-assembly of the jumbo bacteriophage nuclear shell
Bacteria encode myriad defences that target the genomes of infecting bacteriophage, including
restriction–modification and CRISPR–Cas systems 1 . In response, one family of large …
restriction–modification and CRISPR–Cas systems 1 . In response, one family of large …
Structure of the complex I-like molecule NDH of oxygenic photosynthesis
Cyclic electron flow around photosystem I (PSI) is a mechanism by which photosynthetic
organisms balance the levels of ATP and NADPH necessary for efficient photosynthesis 1 , 2 . …
organisms balance the levels of ATP and NADPH necessary for efficient photosynthesis 1 , 2 . …
Identification of a carbonic anhydrase–Rubisco complex within the alpha-carboxysome
C Blikstad, EJ Dugan, TG Laughlin… - Proceedings of the …, 2023 - National Acad Sciences
Carboxysomes are proteinaceous organelles that encapsulate key enzymes of CO 2 fixation—Rubisco
and carbonic anhydrase—and are the centerpiece of the bacterial CO 2 …
and carbonic anhydrase—and are the centerpiece of the bacterial CO 2 …
Iron (III) tosylate catalyzed synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones/thiones via the Biginelli reaction
JT Starcevich, TJ Laughlin, RS Mohan - Tetrahedron Letters, 2013 - Elsevier
The synthesis of dihydropyrimidinones and dihydropyrimidine thiones has attracted interest
due to their biological activities. A common method for their synthesis is the Biginelli reaction…
due to their biological activities. A common method for their synthesis is the Biginelli reaction…
[HTML][HTML] Rubisco forms a lattice inside alpha-carboxysomes
…, C Blikstad, DR Lovejoy, TG Laughlin… - Nature …, 2022 - nature.com
Despite the importance of microcompartments in prokaryotic biology and bioengineering,
structural heterogeneity has prevented a complete understanding of their architecture, …
structural heterogeneity has prevented a complete understanding of their architecture, …
[HTML][HTML] Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules
A Shams, SA Higgins, C Fellmann, TG Laughlin… - Nature …, 2021 - nature.com
Proteins evolve through the modular rearrangement of elements known as domains. Extant,
multidomain proteins are hypothesized to be the result of domain accretion, but there has …
multidomain proteins are hypothesized to be the result of domain accretion, but there has …
[PDF][PDF] Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY
…, TG Laughlin, A Lee, KP Thomas, AE Sy, T Spencer… - Cell reports, 2023 - cell.com
We recently discovered that some bacteriophages establish a nucleus-like replication
compartment (phage nucleus), but the core genes that define nucleus-based phage replication …
compartment (phage nucleus), but the core genes that define nucleus-based phage replication …