Ethical, legal, and practical concerns about recontacting patients to inform them of new information: the case in medical genetics
…, N Sharpe, M Mullen, WS Meschino - American journal of …, 2001 - Wiley Online Library
… Ethics and the law are clear that patients have the right to be informed when a mistake
has been made, and this duty 皋ws from the original relationship. …
has been made, and this duty 皋ws from the original relationship. …
Hereditary breast and ovarian cancers
…, J Grimshaw, C Honeywell, WS Meschino… - Canadian Family …, 2008 - cfp.ca
… Dr Meschino is a Clinical Geneticist at North York General Hospital and Assistant Professor
in the Department of Paediatrics at the University of Toronto. Ms Permaul is a Research …
in the Department of Paediatrics at the University of Toronto. Ms Permaul is a Research …
Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap
…, K Kieser, A MacMillan, WS Meschino… - Journal of medical …, 2018 - jmg.bmj.com
The landscape of genetic testing in ovarian cancer patients has changed dramatically in
recent years. The therapeutic benefits of poly ADP-ribose polymerase (PARP) inhibitors in …
recent years. The therapeutic benefits of poly ADP-ribose polymerase (PARP) inhibitors in …
Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination
…, G DeBoer, MJ Yaffe, SJ Messner, WS Meschino… - Jama, 2004 - jamanetwork.com
ContextCurrent recommendations for women who have a BRCA1 or BRCA2 mutation are to
undergo breast surveillance from age 25 years onward with mammography annually and …
undergo breast surveillance from age 25 years onward with mammography annually and …
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes
…, JL Lauzon, AE Lin, GMS Mancini, WS Meschino… - Nature …, 2012 - nature.com
Megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus
(MPPH) syndromes are sporadic overgrowth disorders associated …
(MPPH) syndromes are sporadic overgrowth disorders associated …
[HTML][HTML] Phenotypic heterogeneity of genomic disorders and rare copy-number variants
…, JS McConnell, B Angle, WS Meschino… - … England Journal of …, 2012 - Mass Medical Soc
Background Some copy-number variants are associated with genomic disorders with
extreme phenotypic heterogeneity. The cause of this variation is unknown, which presents …
extreme phenotypic heterogeneity. The cause of this variation is unknown, which presents …
Molecular mechanism for duplication 17p11. 2—the homologous recombination reciprocal of the Smith-Magenis microdeletion
…, MA Withers, V Kimonis, AM Summers, WS Meschino… - Nature …, 2000 - nature.com
Recombination between repeated sequences at various loci of the human genome are known
to give rise to DNA rearrangements associated with many genetic disorders 1. Perhaps …
to give rise to DNA rearrangements associated with many genetic disorders 1. Perhaps …
[HTML][HTML] International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation
…, L Senter, S Armel, L Bordeleau, WS Meschino… - British journal of …, 2019 - nature.com
Background Women with a BRCA1 or BRCA2 mutation face high risks of breast and ovarian
cancer. In the current study, we report on uptake of cancer screening and risk-reduction …
cancer. In the current study, we report on uptake of cancer screening and risk-reduction …
[PDF][PDF] Effectiveness of screening with annual magnetic resonance imaging and mammography: results of the initial screen from the ontario high risk breast screening …
…, M Horgan, JC Carroll, A Eisen, WS Meschino… - J Clin …, 2014 - cancercareontario.ca
Purpose The Ontario Breast Screening Program expanded in July 2011 to screen women
age 30 to 69 years at high risk for breast cancer with annual magnetic resonance imaging (MRI…
age 30 to 69 years at high risk for breast cancer with annual magnetic resonance imaging (MRI…
[HTML][HTML] Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 …
…, R Salim, T Huang, A Adank, J Zhang, WS Meschino… - The Lancet, 2022 - thelancet.com
Background Existing evidence on the effects of race and ethnicity on pregnancy outcomes is
restricted to individual studies done within specific countries and health systems. We aimed …
restricted to individual studies done within specific countries and health systems. We aimed …