Mitogen-activated signal transduction frequently leads to the induction of the c-myc proto-oncogene,
but the subsequent molecular events downstream of Myc protein expression which …

Increasing evidence supports an important biological role for Myc in the downregulation of
specific gene transcription. Recent studies suggest that c-Myc may suppress promoter activity …

The c-Myc protein strongly stimulates cellular proliferation, inducing cells to exit G0/G1 and
enter the cell cycle. At a molecular level, Myc prevents growth arrest and drives cell cycle …

Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as
many other cell types. Interaction of PDGF BB with the PDGF β receptor (PDGF-βR) activates …

Depression is one of the most prevalent chronic conditions in Canada. It costs an estimated
$14 billion each year in health care expenditures and productivity losses, 1 and it causes …

Cyclin D1 can bind and phosphorylate the product (pRb) of the retinoblastoma gene (RB-1)
and recent evidence suggests pRb, in turn, may regulate cyclin D1 protein expression. In …

Patient A, a 58-year-old woman, arrived in acute distress, febrile and tender in the right upper
abdomen. A computed tomographic (CT) scan showed periduodenal inflammation and …

La dépression compte parmi les problèmes de santé chroniques les plus fréquents au Canada.
Elle coûte, selon les estimations, 14 milliards de dollars chaque année en dépenses de …

We recently identified 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the
rate-limiting enzyme of the mevalonate pathway, as a potential therapeutic target of the head …