A brief history of synthetic biology
The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in the …
back more than a half-century. With the genomics revolution and rise of systems biology in the …
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis
Background Pathological complete response has been proposed as a surrogate endpoint
for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (…
for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (…
[HTML][HTML] The benefits and harms of breast cancer screening: an independent review
The breast cancer screening programmes in the United Kingdom currently invite women
aged 50–70 years for screening mammography every 3 years. Since the time the screening …
aged 50–70 years for screening mammography every 3 years. Since the time the screening …
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
…, N Sharifi, FL Xu, LA Myers, PJ Spevak, DE Cameron… - Nature …, 2005 - nature.com
We report heterozygous mutations in the genes encoding either type I or type II transforming
growth factor β receptor in ten families with a newly described human phenotype that …
growth factor β receptor in ten families with a newly described human phenotype that …
[HTML][HTML] Aneurysm syndromes caused by mutations in the TGF-β receptor
…, DM Milewicz, PJ Coucke, DE Cameron… - … England Journal of …, 2006 - Mass Medical Soc
Background The Loeys–Dietz syndrome is a recently described autosomal dominant aortic-aneurysm
syndrome with widespread systemic involvement. The disease is characterized by …
syndrome with widespread systemic involvement. The disease is characterized by …
[HTML][HTML] Replacement of the aortic root in patients with Marfan's syndrome
…, PS Greene, DE Alejo, DE Cameron… - … England Journal of …, 1999 - Mass Medical Soc
Background Replacement of the aortic root with a prosthetic graft and valve in patients with
Marfan's syndrome may prevent premature death from rupture of an aneurysm or aortic …
Marfan's syndrome may prevent premature death from rupture of an aneurysm or aortic …
[HTML][HTML] based synthetic gene networks
… for toehold switch D in solution phase … D to demonstrate color development, detection of
the reaction can be seen by the naked eye to begin at 25 min and saturates in ∼1 hr (Figure 3D)…
the reaction can be seen by the naked eye to begin at 25 min and saturates in ∼1 hr (Figure 3D)…
The origin and reduction of acoustic noise in doubly salient variable-reluctance motors
DE Cameron, JH Lang… - IEEE Transactions on …, 1992 - ieeexplore.ieee.org
An experimental study of the acoustic noise emitted from an inverter-driven doubly salient
variable-reluctance motor (VRM) is presented. A list of possible noise sources is given. …
variable-reluctance motor (VRM) is presented. A list of possible noise sources is given. …
'Deadman'and'Passcode'microbial kill switches for bacterial containment
Biocontainment systems that couple environmental sensing with circuit-based control of cell
viability could be used to prevent escape of genetically modified microbes into the …
viability could be used to prevent escape of genetically modified microbes into the …
Mechanical heart valves: 50 years of evolution
VL Gott, DE Alejo, DE Cameron - The Annals of thoracic surgery, 2003 - Elsevier
The past 50 years have witnessed remarkable progress in the development of safe,
hemodynamically favorable mechanical heart valves. Starr-Edwards aortic and mitral ball valves …
hemodynamically favorable mechanical heart valves. Starr-Edwards aortic and mitral ball valves …