Aldosterone antagonists in systolic heart failure

AJ Lindblad, GM Allan - Canadian Family Physician, 2014 - cfp.ca
• RALES1: an RCT of 1663 patients with class III or IV HF taking ACEIs and diuretics;
patients received spironolactone or placebo. Results at 24 months:-A statistically significant …

[CITATION][C] Aldosterone antagonists: evidence‐based yet underutilized effective heart failure therapy

CJ Lavie, JJ DiNicolantonio, JH O'Keefe… - Congestive Heart …, 2013 - Wiley Online Library
Standard therapy for heart failure (HF) consists of badrenergic–blocking agents or b-
blockers and either an angiotensin-converting enzyme (ACE) inhibitor or angiotensin …

[PDF][PDF] Aldosterone antagonists–last man standing

PW Armstrong - N Engl J Med, 2011 - jvsmedicscorner.com
The transformation of cardiac care over the past half century has been breathtaking to
witness. In large part, this transformation is due to the advent of new drugs and devices …

Aldosterone antagonists: the most underutilized class of heart failure medications

M Guglin, KE Awad, L Polavaram… - American journal of …, 2007 - Springer
Background Aldosterone antagonists have been proven to be beneficial in severe heart
failure (HF) as a result of systolic dysfunction. We sought to determine if there is a disparity in …

Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure

JM Nappi, A Sieg - Vascular health and risk management, 2011 - Taylor & Francis
Aldosterone is a mineralocorticoid hormone synthesized by the adrenal glands that has
several regulatory functions to help the body maintain normal volume status and electrolyte …

Aldosterone receptor antagonists for heart failure: current status, future indications.

B Pitt, S Rajagopalan - Cleveland Clinic journal of medicine, 2006 - europepmc.org
Many patients with heart failure should receive an aldosterone receptor antagonist, ie, either
spironolactone (Aldactone) or the newer agent eplerenone (Inspra)--in addition to an …

[PDF][PDF] The role of aldosterone receptor antagonists in the management of heart failure: an update

V Nagarajan, M Chamsi-Pasha, WH Tang - Cleve Clin. J. Med, 2012 - scholar.archive.org
The aldosterone receptor antagonists (ARAs) spironolactone (Aldactone) and eplerenone
(Inspra) have become part of standard medical therapy for heart failure, having shown …

Eplerenone is not superior to older and less expensive aldosterone antagonists

S Chatterjee, C Moeller, N Shah, O Bolorunduro… - The American journal of …, 2012 - Elsevier
INTRODUCTION: Eplerenone is publicized to be extremely effective in reducing mortality
from heart failure, with a reasonable side-effect profile. However, it is much more expensive …

Aldosterone antagonists in congestive heart failure.

J Soberman, CC Chafin, KT Weber - Current Opinion in …, 2002 - europepmc.org
The role of aldosterone in the pathophysiology of congestive heart failure (CHF) has long
been recognized. The recent RALES (Randomized Aldactone Evaluation Study) trial …

Aldosterone antagonists in hypertension and heart failure.

F Mantero, G Lucarelli - Annales d'endocrinologie, 2000 - europepmc.org
Spironolactone, a competitive aldosterone receptor antagonist (ARA), has traditionally been
the treatment of first choice in idiopathic hyperaldosteronism (IHA) and for preoperative …