Zopiclone: is it a pharmacologic agent for abuse?

N Cimolai - Canadian family physician, 2007 - cfp.ca
OBJECTIVE To determine whether the hypnosedative drug zopiclone could be an agent for
abuse. SOURCES OF INFORMATION Using MEDLINE and PubMed, English-language …

Zopiclone: a review of its pharmacological properties and therapeutic efficacy as an hypnotic

AN Wadworth, D McTavish - Drugs & Aging, 1993 - Springer
Synopsis Zopiclone is a cyclopyrrolone which is chemically unrelated to the
benzodiazepines and is thought to act on the GABA A receptor complex at a site distinct …

PEM report number 10. Zopiclone

W Inman, K Kubota, G Pearce… - … and Drug Safety, 1993 - Wiley Online Library
The short‐acting, non‐benzodiazepine hypnotic, zopiclone, first marketed as 'Zimovane'in
the United Kingdom in 1989, has been studied by Prescription‐Event Monitoring (PEM) in …

A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience

G Hajak - Drug safety, 1999 - Springer
This review compares the efficacy of zopiclone with that of a number of commonly used short-
, medium-and long-acting benzodiazepines. Zopiclone at dosages of 7.5 mg/day has …

Zopiclone, the third generation hypnotic: a clinical overview.

B Musch, F Maillard - International Clinical Psychopharmacology, 1990 - europepmc.org
Effective and safe hypnotics exist especially since the introduction of benzodiazepines
(BZD) which appeared to bring major advantages over barbiturates. Ideally a new hypnotic …

Zopiclone: is there any dependence and abuse potential?

M Lader - Journal of neurology, 1997 - Springer
Both published and unpublished data concerning the rebound, withdrawal, dependence
and abuse potential of zopiclone have been reviewed. As expected for an hypnotic drug of …

Zopiclone: an update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia

S Noble, HD Langtry, HM Lamb - Drugs, 1998 - Springer
Synopsis Zopiclone is a non-benzodiazepine hypnotic which was first reviewed in Drugs in
1986. At that time, zopiclone had shown hypnotic efficacy superior to that of placebo, but had …

Long term efficacy and withdrawal of zopiclone: a sleep laboratory study.

J Pecknold, R Wilson, P Le Morvan - International Clinical …, 1990 - europepmc.org
The purpose of this study was to evaluate the short, intermediate, and long-term (8 weeks)
effectiveness, as well as the withdrawal effects of zopiclone 7.5 mg. Eleven chronic …

Zopiclone: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic

KL Goa, RC Heel - Drugs, 1986 - Springer
Synopsis: Zopiclone 1 is the first of the cyclopyrrolones, a new class of psychotherapeutic
agents possessing a pharmacological profile of high efficacy and low toxicity similar to that …

Abuse and dependence potential for the non‐benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data

G Hajak, WE Müller, HU Wittchen, D Pittrow… - Addiction, 2003 - Wiley Online Library
Aims The non‐benzodiazepine hypnotics zolpidem and zopiclone, which are indicated for
short‐term treatment of insomnia, were considered originally by physicians as almost devoid …