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Abstract

Tumour necrosis factor alpha and use of infliximab. Safety during pregnancy.

Canadian Family Physician May 2005, 51 (5) 667-668;
Alan Shrim
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Gideon Koren
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  1. Alan Shrim and
  2. Gideon Koren

    Abstract

    QUESTION: A 27-year-old patient of mine with rheumatoid arthritis has been treated with infliximab for the last 5 years. She is planning her first pregnancy. How should I advise her regarding use of infliximab during pregnancy, bearing in mind that infliximab substantially improved her medical condition? ANSWER: Infliximab (Remicade) has not been tested in pregnant animals because it does not interact with non-human tumour necrosis factor (TNF) alpha. Several case reports describing women who used infliximab during pregnancy do not suggest a strong association with adverse pregnancy outcomes. More studies are required to determine infliximab's safety during pregnancy.

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    Canadian Family Physician
    Vol. 51, Issue 5
    1 May 2005
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    Tumour necrosis factor alpha and use of infliximab. Safety during pregnancy.
    Alan Shrim, Gideon Koren
    Canadian Family Physician May 2005, 51 (5) 667-668;

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    Alan Shrim, Gideon Koren
    Canadian Family Physician May 2005, 51 (5) 667-668;
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