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Abstract

Amyotrophic lateral sclerosis: update for family physicians.

Canadian Family Physician December 2006, 52 (12) 1563-1569;
Christen L Shoesmith
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Michael J Strong
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  1. Christen L Shoesmith and
  2. Michael J Strong

    Abstract

    OBJECTIVE To discuss the epidemiology, pathogenesis, diagnosis, expected course, prognosis, and treatment of amyotrophic lateral sclerosis (ALS), a degenerative disorder of the nervous system associated with progressive weakness.

    QUALITY OF EVIDENCE PubMed and the Cochrane Database of Systematic Reviews were searched using the MeSH headings "amyotrophic lateral sclerosis," "therapy," "epidemiology," and "etiology." Articles containing the best available evidence were reviewed. Most provided level II and III evidence. There were some level I drug trials.

    MAIN MESSAGE Amyotrophic lateral sclerosis is associated with progressive dysarthria, dysphagia, and weakness in the extremities. Diagnosis is based on physical examination, electrophysiology, and excluding other confounding conditions. There is no cure for this devastating disorder. Certain treatments, however, can improve survival and quality of life.

    CONCLUSION Because ALS is a complex disease, care of ALS patients is best provided at multidisciplinary clinics that specialize in managing patients with this disorder.

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    Canadian Family Physician
    Vol. 52, Issue 12
    1 Dec 2006
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    Amyotrophic lateral sclerosis: update for family physicians.
    Christen L Shoesmith, Michael J Strong
    Canadian Family Physician Dec 2006, 52 (12) 1563-1569;

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    Amyotrophic lateral sclerosis: update for family physicians.
    Christen L Shoesmith, Michael J Strong
    Canadian Family Physician Dec 2006, 52 (12) 1563-1569;
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