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Research ArticlePractice

Methadone exposure during lactation

Miguel Marcelo Glatstein, Facundo Garcia-Bournissen, Yaron Finkelstein and Gideon Koren
Canadian Family Physician December 2008, 54 (12) 1689-1690;
Miguel Marcelo Glatstein
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Facundo Garcia-Bournissen
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Yaron Finkelstein
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Gideon Koren
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ABSTRACT

QUESTION One of my patients is currently using methadone for maintenance of opioid dependence. She wants to breastfeed. Is breastfeeding safe for her infant?

ANSWER The exposure of infants to methadone through their mothers’ breast milk is minimal. Women using methadone for treatment of opioid dependence should not be discouraged from breastfeeding. The benefits of breastfeeding largely outweigh any theoretical minimal risks.

Methadone is an opioid analgesic used in the treatment of narcotic dependency.1 Its usefulness is related to its long serum half-life, slow onset of action, and lower rate of euphoric effects compared with other opiates. The long elimination half-life of methadone allows gradual decrease in dose. Methadone has been shown to reduce the illicit use of opiates and associated crime,2 and maintenance programs have been shown to reduce the risk of acquiring sexually transmitted infections, including HIV.2 Methadone can be prescribed and legally dispensed for outpatient use, facilitating management of these patients.3

Although chemically different from morphine, methadone has similar clinical analgesic effects. It is well absorbed from the gastrointestinal tract, and therapeutic concentrations are evident in plasma 30 minutes after ingestion.4 Peak plasma concentrations are reached 2 to 4 hours after therapeutic doses. Typically, the elimination half-life ranges between 10 and 18 hours.5 Metabolism and clearance rate of methadone are highly variable. Liver metabolism by cytochrome P450 isoenzymes CYP 3A4 and CYP 2B66 is the main route of elimination.

There is sparse published evidence of exposure of infants to methadone through breast milk. Concentrations of methadone in breast milk are low and remain stable over time.7–9 Methadone doses of 25 to 180 mg/d produce concentrations in milk ranging from 27 to 260 ng/ mL, leading to an average daily methadone ingestion of 0.05 mg (based on an infant’s estimated milk intake of approximately 500 mL/d).10 This ingested amount would be equal, in a 5-kg baby, to the ingestion of less than 1% of the maternal weight–adjusted dose (typical adult dose is 40 to 180 mg/d).10 Even after correcting for slower clearance rate of methadone in neonates as compared with adults, the relative infant dose would not exceed 5% of the maternal weight–adjusted dose.

Methadone offers important therapeutic benefits to the population of opiate-dependent pregnant women that far outweigh the theoretical small risk posed by minimal excretion of the drug into breast milk.11 For 18 years, the American Academy of Pediatrics recommended that methadone was only compatible with breastfeeding at maternal doses below 20 mg/d12; in September 2001, based on the evidence available, the American Academy of Pediatrics lifted this dose restriction. The new statement considers methadone compatible with breastfeeding at any maternal dose.13

Infants born to women using methadone for maintenance can develop neonatal abstinence syndrome (NAS), attributable to methadone withdrawal in the first days of life.14 The commonly observed delay between delivery and appearance of NAS, compared with other opiates, can be explained by the fact that in the early neonatal period the concentrations of methadone in the infant and in the mother are similar. Thereafter, methadone levels decline slowly in the infant according to its long elimination half-life. Malpas et al have suggested that breastfeeding might be beneficial in the treatment of NAS,15,16 although it is not clear if this is because of the beneficial effects of breastfeeding itself or because of the low concentrations of methadone present in breast milk mitigating the withdrawal.

Conclusion

The very low concentrations of methadone in beast milk reported in the literature support the recommendation to not discourage breastfeeding women from using methadone treatment, regardless of the dose.

Acknowledgment

Dr Garcia-Bournissen has received funding from the Clinician Scientist Training Program. This program is funded, fully or in part, by the Ontario Student Opportunity Trust Fund—Hospital for Sick Children Foundation Student Scholarship Program.

Notes

MOTHERISK

Motherisk questions are prepared by the Motherisk Team at the Hospital for Sick Children in Toronto, Ont. Drs Glatstein, Garcia-Bournissen, and Finkelstein are members and Dr Koren is Director of the Motherisk Program. Dr Koren is supported by the Research Leadership for Better Pharmacotherapy during Pregnancy and Lactation. He holds the Ivey Chair in Molecular Toxicology in the Department of Medicine at the University of Western Ontario in London.

Do you have questions about the effects of drugs, chemicals, radiation, or infections in women who are pregnant or breastfeeding? We invite you to submit them to the Motherisk Program by fax at 416 813-7562; they will be addressed in future Motherisk Updates.

Published Motherisk Updates are available on the Canadian Family Physician website (www.cfp.ca) and also on the Motherisk website (www.motherisk.org).

Footnotes

  • Competing interests

    None declared

  • Copyright© the College of Family Physicians of Canada

References

  1. ↵
    DaweSHarnettPReducing potential for child abuse among methadone-maintained parents: results from a randomized controlled trialJ Subst Abuse Treat200732438190Epub 2006 Dec 8
    OpenUrlCrossRefPubMed
  2. ↵
    DaleyMArgeriouMMcCartyDCallahanJJJrShepardDSWilliamsCNThe costs of crime and the benefits of substance abuse treatment for pregnant womenJ Subst Abuse Treat200019444558
    OpenUrlCrossRefPubMed
  3. ↵
    KintzPVillainMDumestre-TouletVCapolaghiBCirimeleVMethadone as a chemical weapon: two fatal cases involving babiesTher Drug Monit20052767413
    OpenUrlCrossRefPubMed
  4. ↵
    LoimerNSchmidRThe use of plasma level to optimize maintenance treatmentDrug Alcohol Depend19923032416
    OpenUrlCrossRefPubMed
  5. ↵
    RobinsonAEWilliamsFMThe distribution of methadone in manJ Pharm Pharmacol19712353538
    OpenUrlPubMed
  6. ↵
    TotahRASheffelsPRobertsTWhittingtonDThummelKKharaschEDRole of CYP2B6 in stereoselective human methadone metabolismAnesthesiology2008108336374
    OpenUrlPubMed
  7. ↵
    Wojnar-HortonREKristensenJHYappPIlettKFDusciLJHackettLPMethadone distribution and excretion into breast milk of clients in a methadone maintenance programmeBr J Clin Pharmacol19974465437
    OpenUrlCrossRefPubMed
  8. LiuAJNananRMethadone maintenance and breastfeeding in the neonatal periodPediatrics2008121486970
    OpenUrlFREE Full Text
  9. ↵
    Abdel-LatifMEPinnerJClewsSCookeFLuiKOeiJEffects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent mothersPediatrics20061176e11639
    OpenUrlAbstract/FREE Full Text
  10. ↵
    MeitesEOpiate exposure in breastfeeding newbornsJ Hum Lact200723113
    OpenUrlFREE Full Text
  11. ↵
    GeraghtyBGrahamEALoganBWeissELMethadone levels in breast milkJ Hum Lact199713322730
    OpenUrlAbstract/FREE Full Text
  12. ↵
    American Academy of Pediatrics, Committee on DrugsThe transfer of drugs and other chemicals into human breast milkPediatrics198372337583
    OpenUrlAbstract/FREE Full Text
  13. ↵
    American Academy of Pediatrics, Committee on Drugs: The transfer of drugs and other chemical into human milkPediatrics2001108377689
    OpenUrlAbstract/FREE Full Text
  14. ↵
    PhilippBLMerewoodAO’BrienSMethadone and breastfeeding: new horizonsPediatrics20031116 Pt 1142930
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  15. ↵
    MalpasTJHorwoodJDarlowBABreastfeeding reduces the severity of neontatal abstinence syndromeJ Pediatr Child Health199733A38
    OpenUrl
  16. ↵
    MalpasTJDarlowBANeonatal abstinence syndrome following abrupt cessation of breastfeedingN Z Med J19991121080123
    OpenUrlPubMed
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Canadian Family Physician: 54 (12)
Canadian Family Physician
Vol. 54, Issue 12
1 Dec 2008
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Methadone exposure during lactation
Miguel Marcelo Glatstein, Facundo Garcia-Bournissen, Yaron Finkelstein, Gideon Koren
Canadian Family Physician Dec 2008, 54 (12) 1689-1690;

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Miguel Marcelo Glatstein, Facundo Garcia-Bournissen, Yaron Finkelstein, Gideon Koren
Canadian Family Physician Dec 2008, 54 (12) 1689-1690;
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