Dabigatran (twice daily) | | | |
• Half-life = 14 h | Normal renal function or mild impairment (eGFR > 50 mL/min) | Last dose: 2 d before surgery (skip 2 doses) | Last dose: 3 d before surgery (skip 4 doses) |
• Half-life = 15–18 h | Moderate renal impairment (eGFR 30–50 mL/min) | Last dose: 3 d before surgery (skip 4 doses) | Last dose: 4–5 d before surgery (skip 6–8 doses) |
Rivaroxaban (once daily) | | | |
• Half-life = 9 h | Normal renal function or mild to moderate impairment (eGFR > 30 mL/min) | Last dose: 2 d before surgery (skip 1 dose) | Last dose: 3 d before surgery (skip 2 doses) |
Apixaban (twice daily) | | | |
• Half-life = 9 h | Normal renal function or mild to moderate impairment (eGFR > 30 mL/min) | Last dose: 2 d before surgery (skip 1 dose) | Last dose: 3 d before surgery (skip 4 doses) |