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Research ArticlePractice

Brief resolved unexplained event

New diagnosis in infants

Karen Arane, Ilene Claudius and Ran D. Goldman
Canadian Family Physician January 2017; 63 (1) 39-41;
Karen Arane
MSc
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Ilene Claudius
MD
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Ran D. Goldman
MD FRCPC
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  • For correspondence: rgoldman@cw.bc.ca
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Abstract

Question For many years, the term apparent life-threatening event (ALTE) was associated with sudden infant death syndrome, and parents who described an acute event in their infants were sent to the hospital for admission. I understand that for infants new terminology is recommended. What is the current approach to a near-death experience of an infant?

Answer A recent clinical practice guideline revised the name and definition of an ALTE to a brief resolved unexplained event (BRUE). The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following BRUE symptoms: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination are completed, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness. Low-risk infants should not be admitted to the hospital and overtesting is discouraged.

A near-death experience of an infant is a life-changing experience for parents.1 An apparent life-threatening event (ALTE) is a constellation of unexpected events that are frightening to the observer.2 In 80% to 90% of situations, the infant is free of symptoms on arrival to the hospital.3 Apparent life-threatening events account for approximately 0.6% to 1.7% of all emergency department (ED) visits for infants younger than 1 year of age, with a median age of 1 to 3 months.1,4

Before 1986, incidents of infantile apnea (preceding the term ALTE) were classified as a near-miss for sudden infant death syndrome (SIDS).5 However, a key distinction between SIDS and infantile apnea was made when no direct correlation between the 2 was found, leading to the term ALTE replacing near-miss SIDS.6 Apparent life-threatening event was defined as any event that was frightening to the observer and consisted of a combination of apnea, colour change, muscle tone change, and choking or gagging.6 Unlike other medical conditions, this definition was broad and vague, and relied heavily on the subjective report of the caregiver rather than on pathophysiology.

The term ALTE describes a symptom, not a final diagnosis. The list of conditions that might result in ALTE is extensive. Gastroesophageal reflux disease, seizures, respiratory diseases such as pertussis and bronchiolitis, serious bacterial infections, and nonaccidental trauma have been shown to cause ALTE in infants.7,8 Less common diagnoses include arrhythmias such as prolonged QT syndrome,9 metabolic disorders, and facial or airway dysmorphisms.10,11 Most conditions can be considered based on a physical examination or a detailed history.

Routine screening for these diseases was found to be extraneous.12 Several retrospective studies have investigated the effectiveness of routine laboratory work in infants with ALTE, resulting in no evidence that routine testing improved identification of a cause.12,13 One study from New York14 involving 243 patients diagnosed with an ALTE reported that out of 3776 tests, only 5.9% contributed to reaching a diagnosis.

With the initial uncertainty about the association between ALTE and SIDS, great measures were taken to evaluate infants with ALTE in the ED setting and to monitor them as inpatients, and many infants were discharged with home apnea monitors.15 Over the past decade studies revealed low rates of severe conditions associated with ALTE.12 While still considered an alarming phenomenon, more than 83% of children in a recent retrospective Italian study had a complete resolution of symptoms spontaneously or after simple tactile stimulation.3 Among 59 admitted patients from California, all younger than age 1 and previously healthy, only 14% required subsequent clinical follow-up that necessitated admission and hospitalization.16

Old condition, new name

In April 2016 the American Academy of Pediatrics published a clinical practice guideline addressing the need for a new definition and classification of what was previously known as an ALTE.17 Adopting the term brief resolved unexplained event (BRUE), the authors wanted to emphasize the transient nature and lack of clear cause for the incident, while eliminating the fear that the term ALTE instilled. The new guidelines provide clearly defined symptoms, allowing the physician to assess the level of risk for patients and provide management recommendations for low-risk infants.

Diagnosis and treatment

The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following symptoms of BRUE: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness (Table 1).17 As outlined in Table 2,17 infants can be risk stratified into the low-risk BRUE group if they meet the following criteria: are older than 60 days of age, experience a single BRUE with a duration of less than 1 minute, have reassuring history and physical examination findings, do not require cardiopulmonary resuscitation by a medical provider, and are not considerably premature (≥ 32 weeks’ gestation at birth and ≥ 45 weeks’ postconceptional age at the time of the BRUE). Recommended treatment as outlined by the American Academy of Pediatrics guideline for those who are at low risk of BRUE focuses on at-home education for caregivers. This includes providing basic information about BRUE, establishing a follow-up treatment plan, and offering cardiopulmonary resuscitation training resources.

View this table:
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Table 1.

Differences between BRUE and ALTE classifications

View this table:
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Table 2.

Characteristics of infants at low risk of BRUE

In the ED, the clinician can monitor the low-risk patient briefly (1 to 4 hours) with continuous pulse oximetry and serial observations to ensure that vital signs and symptomatology remain stable. Physicians might also consider obtaining pertussis testing, as well as a 12-lead electrocardiogram to eliminate channelopathies, based on clinical suspicion.

The most considerable change from previous practice is the emphasis on not admitting patients to the hospital merely for the purpose of cardiopulmonary monitoring and also on limiting overtesting. Performing no tests might be challenging to some physicians,18 especially under pressure from concerned caregivers. Nevertheless, the guidelines stress the lack of benefit of generic laboratory work in low-risk patients.

Specific recommendations are not offered for patients who fall into a higher-risk category; it is likely that a more thorough evaluation and period of observation is appropriate for these infants.

Conclusion

A new clinical practice guideline17 has recently been established to assist clinicians in managing BRUEs in infants classified as low or high risk. The new guidelines might help decrease unnecessary and costly medical interventions, improve patient outcomes, and assist in future research in the field.

Notes

PRETx Pediatric Research in Emergency Therapeutics

Child Health Update is produced by the (PRETx) program (www.pretx.org) at the BC Children’s Hospital in Vancouver, BC. Ms Arane and Dr Claudius are members and Dr Goldman is Director of the PRETx program. The mission of the PRETx program is to promote child health through evidence-based research in therapeutics in pediatric emergency medicine.

Do you have questions about the effects of drugs, chemicals, radiation, or infections in children? We invite you to submit them to the PRETx program by fax at 604 875–2414; they will be addressed in future Child Health Updates. Published Child Health Updates are available on the Canadian Family Physician website (www.cfp.ca).

Footnotes

  • This article is eligible for Mainpro+ certified Self-Learning credits. To earn credits, go to www.cfp.ca and click on the Mainpro+ link.

  • La traduction en français de cet article se trouve à www.cfp.ca dans la table des matières du numéro de janvier 2017 à la page e15.

  • Competing interests

    None declared

  • Copyright© the College of Family Physicians of Canada

References

  1. 1.↵
    1. Sahewalla R,
    2. Gupta D,
    3. Kamat D
    . Apparent life-threatening events: an overview. Clin Pediatr (Phila) 2016;55(1):5-9. Epub 2015 Jun 19.
    OpenUrlFREE Full Text
  2. 2.↵
    1. Fu LY,
    2. Moon RY
    . Apparent life-threatening events: an update. Pediatr Rev 2012;33(8):361-8.
    OpenUrlFREE Full Text
  3. 3.↵
    1. Vigo A,
    2. Balagna R,
    3. Brazzi L,
    4. Costagliola G,
    5. Gregoretti C,
    6. Lupica MM,
    7. et al
    . Apparent life-threatening events. Pediatr Emerg Care 2016 Jul 9. Epub ahead of print.
  4. 4.↵
    1. Monti MC,
    2. Borrelli P,
    3. Nosetti L,
    4. Tajè S,
    5. Perotti M,
    6. Bonarrigo D,
    7. et al
    . Incidence of apparent life-threatening events and post-neonatal risk factors. Acta Paediatr 2016 Mar 6. Epub ahead of print.
  5. 5.↵
    1. Friedman SB,
    2. Bergman AB,
    3. Mandell F,
    4. Vales-Dapena MA,
    5. Connelly JP,
    6. Merritt TA
    . Statement on terminology from the national SIDS foundation. Pediatrics 1981;68(4):543.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring, Sept 29 to Oct 1, 1986. Pediatrics 1987;79(2):292-9.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Okada K,
    2. Miyako M,
    3. Honma S,
    4. Wakabayashi Y,
    5. Sugihara S,
    6. Osawa M
    . Discharge diagnoses in infants with apparent life-threatening event. Pediatr Int 2003;45(5):560-3.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Davies F,
    2. Gupta R
    . Apparent life-threatening events in infants presenting to an emergency department. Emerg Med J 2002;19(1):11-6.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Goldhammer EI,
    2. Zaid G,
    3. Tal V,
    4. Jaffe M,
    5. Abinader EG
    . QT dispersion in infants with apparent life-threatening events syndrome. Pediatr Cardiol 2002;23(6):605-7.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Guilleminault C,
    2. Pelayo R,
    3. Leger D,
    4. Philip P
    . Apparent life-threatening events, facial dysmorphia and sleep-disordered breathing. Eur J Pediatr 2000;159(6):444-9.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Hartmann H,
    2. Seidenberg J,
    3. Noyes JP,
    4. O’Brien L,
    5. Poets CF,
    6. Samuels MP,
    7. et al
    . Small airway patency in infants with apparent life-threatening events. Eur J Pediatr 1998;157(1):71-4.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Tieder JS,
    2. Altman RL,
    3. Bonkowsky JL,
    4. Brand DA,
    5. Claudius I,
    6. Cunningham DJ,
    7. et al
    . Management of apparent life-threatening events in infants: a systematic review. J Pediatr 2013;163(1):94.9.e1-6. Epub 2013 Feb 14.
    OpenUrl
  13. 13.↵
    1. De Piero AD,
    2. Teach SJ,
    3. Chamberlain JM
    . ED evaluation of infants after an apparent life-threatening event. Am J Emerg Med 2004;22(2):83-6.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Brand DA,
    2. Altman RL,
    3. Purtill K,
    4. Edwards KS
    . Yield of diagnostic testing in infants who have had an apparent life-threatening event. Pediatrics 2005;115(4):885-93. Erratum in: Pediatrics 2005;116(3):802–3.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Fu LY,
    2. Moon RY
    . Apparent life-threatening events (ALTEs) and the role of home monitoring. Pediatr Rev 2007;28(6):203-8.
    OpenUrlFREE Full Text
  16. 16.↵
    1. Claudius I,
    2. Keens T
    . Do all infants with apparent life-threatening events need to be admitted? Pediatrics 2007;119(4):679-83.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Tieder JS,
    2. Bonkowsky JL,
    3. Etzel RA,
    4. Franklin WH,
    5. Gremse DA,
    6. Herman B,
    7. et al
    . Brief resolved unexplained events (formerly apparent life-threatening events) and evaluation of lower-risk infants. Pediatrics 2016;137(5). Epub 2016 Apr 25. Erratum in: Pediatrics 2016;138(2).
  18. 18.↵
    1. PerryUndem Research/Communication.
    Unnecessary tests and procedures in the health care system: what physicians say about the problem, the causes, and the solutions. Philadelphia, PA: American Board of Internal Medicine; 2014. Available from: www.choosingwisely.org/wp-content/uploads/2015/04/Final-Choosing-Wisely-Survey-Report.pdf. Accessed 2016 Nov 25.
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Brief resolved unexplained event
Karen Arane, Ilene Claudius, Ran D. Goldman
Canadian Family Physician Jan 2017, 63 (1) 39-41;

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Karen Arane, Ilene Claudius, Ran D. Goldman
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