Skip to main content

Main menu

  • Home
  • Articles
    • Current
    • Published Ahead of Print
    • Archive
    • Supplemental Issues
    • Collections - French
    • Collections - English
  • Info for
    • Authors & Reviewers
    • Submit a Manuscript
    • Advertisers
    • Careers & Locums
    • Subscribers
    • Permissions
  • About CFP
    • About CFP
    • About the CFPC
    • Editorial Advisory Board
    • Terms of Use
    • Contact Us
  • Feedback
    • Feedback
    • Rapid Responses
    • Most Read
    • Most Cited
    • Email Alerts
  • Blogs
    • Latest Blogs
    • Blog Guidelines
    • Directives pour les blogues
  • Mainpro+ Credits
    • About Mainpro+
    • Member Login
    • Instructions
  • Other Publications
    • http://www.cfpc.ca/Canadianfamilyphysician/
    • https://www.cfpc.ca/Login/
    • Careers and Locums

User menu

  • My alerts

Search

  • Advanced search
The College of Family Physicians of Canada
  • Other Publications
    • http://www.cfpc.ca/Canadianfamilyphysician/
    • https://www.cfpc.ca/Login/
    • Careers and Locums
  • My alerts
The College of Family Physicians of Canada

Advanced Search

  • Home
  • Articles
    • Current
    • Published Ahead of Print
    • Archive
    • Supplemental Issues
    • Collections - French
    • Collections - English
  • Info for
    • Authors & Reviewers
    • Submit a Manuscript
    • Advertisers
    • Careers & Locums
    • Subscribers
    • Permissions
  • About CFP
    • About CFP
    • About the CFPC
    • Editorial Advisory Board
    • Terms of Use
    • Contact Us
  • Feedback
    • Feedback
    • Rapid Responses
    • Most Read
    • Most Cited
    • Email Alerts
  • Blogs
    • Latest Blogs
    • Blog Guidelines
    • Directives pour les blogues
  • Mainpro+ Credits
    • About Mainpro+
    • Member Login
    • Instructions
  • RSS feeds
  • Follow cfp Template on Twitter
  • LinkedIn
  • Instagram
Review ArticlePractice

Diagnosis and management of psoriasis

Whan B. Kim, Dana Jerome and Jensen Yeung
Canadian Family Physician April 2017; 63 (4) 278-285;
Whan B. Kim
Dermatology resident at the University of Ottawa in Ontario.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dana Jerome
Head of the Division of Rheumatology at the University of Toronto in Ontario.
MD MEd FRCPC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jensen Yeung
Lecturer in the Division of Dermatology at the University of Toronto.
MD FRCPC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jensen.yeung@utoronto.ca
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF
Loading

Abstract

Objective To provide primary care clinicians with an up-to-date and practical overview of the diagnosis and management of psoriasis.

Quality of evidence PubMed, MEDLINE, EMBASE, and Cochrane databases were searched for relevant meta-analyses, randomized controlled trials, systematic reviews, and observational studies about the diagnosis and management of psoriasis.

Main message Psoriasis is a chronic, multisystem inflammatory disease with predominantly skin and joint involvement. Beyond the physical dimensions of disease, psoriasis has an extensive emotional and psychosocial effect on patients, affecting social functioning and interpersonal relationships. As a disease of systemic inflammation, psoriasis is associated with multiple comorbidities, including cardiovascular disease and malignancy. The diagnosis is primarily clinical and a skin biopsy is seldom required. Depending on the severity of disease, appropriate treatment can be initiated. For mild to moderate disease, first-line treatment involves topical therapies including corticosteroids, vitamin D3 analogues, and combination products. These topical treatments are efficacious and can be safely initiated and prescribed by primary care physicians. Patients with more severe and refractory symptoms might require further evaluation by a dermatologist for systemic therapy.

Conclusion Many patients with psoriasis seek initial evaluation and treatment from their primary care providers. Recognition of psoriasis, as well as its associated medical and psychiatric comorbidities, would facilitate timely diagnosis and appropriate management with effective and safe topical therapies and other medical and psychological interventions, as needed. More severe and refractory cases might warrant referral to a dermatologist for further evaluation and possible systemic therapy.

Psoriasis is a chronic disease that is estimated to affect approximately 1.7% of the Canadian population.1 Psoriasis is a multisystem inflammatory disease with predominantly skin and joint involvement. It has a bimodal age of onset (16 to 22 and 57 to 60 years)2 and affects both sexes equally.3 Pathogenesis is multifactorial, involving dysregulated inflammation and genetic associations.4 Beyond the physical dimensions of disease, psoriasis has an extensive emotional and psychosocial effect on patients; it can result in stigmatization, poor self-esteem, and increased stress, affecting social functioning and interpersonal relationships.1

Despite its considerable effect on quality of life, psoriasis is underdiagnosed and undertreated.5,6 This calls for a better understanding of the disease and the available treatment options to provide optimal management of psoriasis. Because many patients seek initial evaluation and treatment at the primary care level, family physicians are well positioned to provide diagnosis and initiate treatment of psoriasis. In this review, we provide an update and the latest evidence for a practical and comprehensive overview of the diagnosis and treatment of psoriasis.

Quality of evidence

Using the term psoriasis, we searched the PubMed, MEDLINE, EMBASE, and Cochrane databases for meta-analyses, randomized controlled trials (RCTs), systematic reviews, and observational studies. We included studies published in English between January 1991 and December 2015. We also manually searched the references of relevant articles retrieved.

Main message

Diagnosis.

The diagnosis of psoriasis is primarily clinical. There are different clinical types of psoriasis (Table 1),1 the most common of which is chronic plaque psoriasis, affecting 80% to 90% of patients with psoriasis. The hallmark of classic plaque psoriasis is well-demarcated, symmetric, and erythematous plaques with overlying silvery scale (Figure 1). Plaques are typically located on the scalp, trunk, buttocks, and extremities but can occur anywhere on the body. Patients might demonstrate nail involvement, which can present without concomitant plaques (Figure 2). Active lesions might be itchy or painful. Psoriasis can also present as an isomorphic response, where new lesions develop on previously normal skin that has sustained trauma or injury. The severity of disease can be helpful in guiding management and is classified as mild, moderate, and severe (Table 2).1

Figure 1.
  • Download figure
  • Open in new tab
Figure 1.

Plaque psoriasis is characterized by well-demarcated and erythematous plaques with silvery scale:

A) Plaque psoriasis on the elbow; B) Psoriasis on the trunk, marked by confluent red, well-demarcated, scaly plaques; C) Psoriasis on the dorsal foot and metatarsophalangeal joint with psoriatic nails showing dystrophy; D) Psoriasis in the postauricular area, which is a common site of involvement.

Figure 2.
  • Download figure
  • Open in new tab
Figure 2.

Patients with psoriasis might have nail involvement, which can present without concomitant plaques:

A) Psoriatic nails, consisting of pitting, distal onycholysis, subungual hyperkeratosis, and crumbling; B) Leukonychia and splinter hemorrhages; C) Distal onycholysis and oil drop sign.

View this table:
  • View inline
  • View popup
Table 1.

Clinical manifestations of psoriasis

View this table:
  • View inline
  • View popup
Table 2.

Measures of disease severity

Evaluation and differential diagnosis.

Less common variants of psoriasis include inverse psoriasis, pustular psoriasis, guttate psoriasis, erythrodermic psoriasis, and annular psoriasis (Figures 3 to 6). These variants can be differentiated from the common plaque type by morphology. Differential diagnoses include atopic dermatitis, contact dermatitis, lichen planus, secondary syphilis, mycosis fungoides, tinea corporis, and pityriasis rosea (Table 3). Careful observation often yields the diagnosis. For more atypical presentations, a skin biopsy might be helpful.

Figure 3.
  • Download figure
  • Open in new tab
Figure 3.

Annular psoriasis on the back: Annular psoriasis is characterized by well-demarcated, erythematous, and scaly plaques with central clearing.

Figure 4.
  • Download figure
  • Open in new tab
Figure 4.

Pustular psoriasis on the palm

Figure 5.
  • Download figure
  • Open in new tab
Figure 5.

Guttate psoriasis, which developed 12 d after onset of streptococcal pharyngitis

Figure 6.
  • Download figure
  • Open in new tab
Figure 6.

Approaching erythrodermic psoriasis

View this table:
  • View inline
  • View popup
Table 3.

Differential diagnoses and distinguishing clinical features

Associated comorbidities.

There is increasing evidence that psoriasis is a disease of systemic inflammation with ramifications for multiple organ systems. Thus, patients with psoriasis should receive appropriate therapy for psoriasis and management of comorbid conditions to improve long-term outcomes.

Psoriatic arthritis: Psoriatic arthritis affects approximately 30% of patients with psoriasis.7 The skin disease most commonly precedes the joint disease by about a decade, ranging from 7 to 12 years.8 Psoriatic arthritis is now known to be a more severe disease than previously recognized.9 Studies have shown that almost 47% of patients can develop erosive disease within the first 2 years.10 The presentation of arthritis can vary. A common feature is dactylitis, in which the entire digit becomes swollen, often called a sausage digit. Psoriatic arthritis can affect small joints and large joints, presenting as joint swelling—either oligoarticular or polyarticular. Psoriatic arthritis can also affect the axial skeleton, presenting as inflammatory back pain. Recent literature tells us that the sooner the inflammatory process is halted, the more likely patient function, radiologic damage, and long-term prognosis will improve considerably.8 Despite this, psoriatic arthritis is often overlooked; 30% of patients with known psoriasis followed at dermatology clinics were found to have undiagnosed psoriatic arthritis.11 Patients with scalp psoriasis, nail features of psoriasis, and intergluteal or perianal disease have a higher risk of psoriatic arthritis.12 Although we should have a high index of suspicion for all patients, special attention should be paid to patients with these features. Early detection is key. Many of the therapies currently available for the skin component of the disease are also highly effective in the treatment of joints.

Cardiovascular disease and diabetes: Psoriasis has also been linked to increased risk of cardiovascular disease and diabetes in an observational study with 78 061 women and a cross-sectional study with 3236 patients with psoriasis.13,14 Other population-based studies have also shown a strong association between psoriasis and metabolic syndrome (odds ratio of 3.58, P = .008).15

Malignancy: Psoriasis has also been associated with a low but elevated risk of non-Hodgkin lymphoma and cutaneous T cell lymphoma in a study of 2718 patients with psoriasis (odds ratio of 2.95, 95% CI 1.83 to 4.76).16

Psychiatric illness: Psychiatric illnesses, including depression (prevalence of up to 60%) and anxiety, can also commonly accompany psoriasis. This warrants assessment of the psychosocial well-being of patients, and clinicians should consider psychological interventions as needed.17

Management.

Although there is no cure for psoriasis, there are multiple effective treatment options (Figure 7). Topical therapy is the standard of care for treatment of mild to moderate disease. A large proportion of patients would benefit from topical therapy, which can be initiated at the primary care level. If topical agents do not elicit an adequate response or if they are not practical owing to the affected body surface area, these patients can be referred for assessment by a dermatologist, at which point systemic therapy with topical adjuncts might be more suitable. Presence of psoriatic arthritis might also call for systemic therapies in collaboration with a rheumatologist.

Figure 7.
  • Download figure
  • Open in new tab
Figure 7.

Treatment algorithm for healthy adult men with chronic plaque psoriasis (> 5% BSA) without psoriatic arthritis

BB—broadband, BSA—body surface area, NB—narrowband, PUVA—psoralen plus UVA, UV—ultraviolet.

Topical therapy

Corticosteroids: Considered the cornerstone of topical treatment, corticosteroids are often well tolerated and effective for patients with mild psoriasis.18 Despite widespread use for more than half a century, large RCTs and head-to-head comparisons are rather limited. A Cochrane review of 177 RCTs, however, showed that corticosteroids performed at least as well as vitamin D3 analogues, with standardized mean differences ranging from −0.89 (95% CI −1.06 to −0.72) to −1.56 (95% CI −1.87 to −1.26) for potent and very potent corticosteroids, respectively.19 Overall, topical steroids in various formulations, strengths, and combinations are efficacious initial therapy for rapid control of symptoms. For instance, salicylic acid, a keratolytic agent, can be combined with steroid therapy to help treat plaques with thicker scales, for better penetration of medication. Although uncommon, long-term use is complicated by possible side effects of local skin changes, tachyphylaxis, and hypothalamic-pituitary-adrenal axis suppression.1

Vitamin D3 analogues: Calcipotriol, a vitamin D3 analogue, is a first-line topical agent for treatment of plaque psoriasis and moderately severe scalp psoriasis.1 It reduces symptoms by modulating keratinocyte proliferation and differentiation, and by inhibiting T lymphocyte activity. Multiple randomized trials have shown calcipotriol to be safe and efficacious for patients with mild plaque psoriasis and not inferior to most corticosteroids with respect to efficacy.20,21 Further, a Cochrane meta-analysis of 177 RCTs showed that vitamin D3 analogues are more effective than all other topical medications, except the most potent of corticosteroids; standardized mean difference ranged from −0.7 (95% CI −1.04 to −0.30) to −1.66 (95% CI −2.66 to −0.67) for twice-daily becocalcidiol and once-daily paricalcitol, respectively.19 Given their efficacy and safety profile, vitamin D3 analogues are commonly used as monotherapy or, more often, as combination therapy. Side effects include mild irritant dermatitis and rarely hypercalcemia with excessive use. These agents should not be used in combination with salicylic acid or before phototherapy.

Combination products: Combination of calcipotriol and betamethasone dipropionate was shown to be more effective for psoriasis than either monotherapy alone in a Cochrane review of 177 RCTs.19 Clinical trials have also demonstrated reduced incidence of adverse events with concomitant or sequential use of vitamin D3 analogues and topical corticosteroids.22 Based on a systematic review of 6 RCTs with 6050 patients, the mean reduction in Psoriasis Area and Severity Index score at 4 weeks was 74% with combination therapy, compared with 59% and 63% with calcipotriol and betamethasone dipropionate, respectively.23 The combination gel is well tolerated and can be applied once daily, avoiding the facial, genital, and flexural areas.

Systemic therapy

Phototherapy: Phototherapy is a mainstay treatment of moderate to severe psoriasis, especially in psoriasis that is unresponsive to topical agents.1 It is available as psoralen plus UVA, broadband UVB, and narrowband UVB (NB-UVB). Owing to its efficacy and safety advantages, as shown in multiple RCTs,24 NB-UVB therapy is often used as first-line treatment. In fact, NB-UVB therapy can be given to almost any patient, including children and pregnant women. There is no evidence that NB-UVB increases the risk of skin malignancy.25 Despite its safety, limited availability of phototherapy centres (fewer than 50 centres across Canada) and the need for frequent visits (3 times a week for 3 months initially) renders this option extremely inconvenient for patients.

Acitretin: Acitretin is a synthetic retinoid indicated for treatment of moderate to severe psoriasis. Its role as an adjunctive therapy to other systemic agents has been well documented to enhance efficacy, lower doses, and reduce occurrence of side effects.26–28 However, large robust trials studying its efficacy and safety as monotherapy are lacking. Common side effects include mucocutaneous dryness, arthralgia, gastrointestinal upset, and photosensitivity. This medication can sometimes cause transaminitis and elevated triglyceride levels. Acitretin is a potent teratogen that is best avoided in women of childbearing age and potential; it is recommended that women not get pregnant for 3 years after discontinuing the medication.29

Methotrexate: Methotrexate is an inhibitor of folate biosynthesis, used for its cytostatic and anti-inflammatory properties in the treatment of moderately severe to severe psoriasis, as well as psoriatic arthritis.1 Despite substantial clinical experience with this drug, large robust studies of its efficacy and safety are extremely limited. One randomized, double-blind, placebo-controlled study showed 75% improvement in Psoriasis Area and Severity Index score in almost 40% of patients with methotrexate, compared with 18.9% of patients with placebo at 16 weeks.30 A well-known side effect is hepatotoxicity.31 Other more common side effects include nausea, vomiting, diarrhea, and fatigue.

Cyclosporine: Cyclosporine is a calcineurin inhibitor indicated for treatment of moderate to severe psoriasis.1 There is also some evidence for its efficacy in psoriatic arthritis.32,33 It has been shown to cause significant improvement or complete remission in 80% to 90% of patients within 12 to 16 weeks in a 1-year open, multicentre, randomized study with 400 patients.34 Advantages over other systemic agents include rapid onset of action and less concern about myelosuppression or hepatotoxicity. Adverse effects include nephrotoxicity, hypertension, elevated triglyceride levels, gingival hyperplasia, tremors, hypomagnesemia, hyperkalemia, numerous drug interactions, and malignancies such as skin cancers and lymphoma.35

Biologic therapy: Biologics have emerged as highly potent treatment options in patients for whom traditional systemic therapies fail to achieve an adequate response, are not tolerated owing to adverse effects, or are unsuitable owing to comorbidities.4 There is no single sequence in which biologics should be initiated or switched4; however, a meta-analysis of pivotal phase III studies has shown that infliximab might be the most efficacious, followed by ustekinumab, adalimumab, and etanercept.36 Choice of therapy depends on clinical needs, benefits and risks, patient preferences, and cost effectiveness (around $20 000 to $25 000 a year on average). Previous randomized trials and retrospective studies have shown that biologic therapy was not associated with increased risk of malignancy or serious infection.37,38

Conclusion

Psoriasis is a multisystem inflammatory disease that is underdiagnosed and undertreated despite its prevalence and considerable effect on quality of life. Beyond skin and joint involvement, psoriasis is also associated with an array of important medical and psychiatric comorbidities that require timely therapy to improve long-term outcomes. Primary caregivers are well positioned to provide diagnosis and treatment of patients who seek initial evaluation at the primary care level. Patients with psoriasis for whom topical therapy fails can be referred to a dermatologist for further evaluation.

Notes

EDITOR’S KEY POINTS

  • Psoriasis is a chronic, multisystem inflammatory disease that is underdiagnosed and undertreated despite its prevalence and considerable effect on quality of life.

  • Beyond skin and joint involvement, psoriasis is also associated with an array of important medical and psychiatric comorbidities, including psoriatic arthritis, cardiovascular disease, diabetes, malignancy, depression, and anxiety, that require timely therapy to improve long-term outcomes.

  • Severity of disease can be helpful in guiding management. A variety of topical treatments are safe and effective for mild to moderate disease. More severe disease might require systemic therapy, including phototherapy, acitretin, methotrexate, cyclosporine, or biologic therapy.

Footnotes

  • This article is eligible for Mainpro+ certified Self-Learning credits. To earn credits, go to www.cfp.ca and click on the Mainpro+ link.

  • This article has been peer reviewed.

  • La traduction en français de cet article se trouve à www.cfp.ca dans la table des matières du numéro d’avril 2017 à la page e210.

  • Competing interests

    Dr Yeung has been a speaker, consultant, and investigator for AbbVie, Allergan, Amgen, Astellas, Boehringer Ingelheim, Celgene, Centocor, Coherus, Dermira, Eli Lilly, Forward, Galderma, Janssen, Leo, Medimmune, Novartis, Pfizer, and Takeda. Dr Jerome has participated in advisory board meetings for AbbVie, Celgene, UCB, Amgen, and Novartis.

  • Contributors

    All authors contributed to the literature review and analysis, and to preparing the manuscript for submission.

  • Copyright© the College of Family Physicians of Canada

References

  1. 1.↵
    1. Canadian Psoriasis Guidelines Committee.
    Canadian guidelines for the management of plaque psoriasis. Ottawa, ON: Canadian Dermatology Association; 2009.
  2. 2.↵
    1. Griffiths CE,
    2. Barker JN
    . Pathogenesis and clinical features of psoriasis. Lancet 2007;370(9583):263-71.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Levine D,
    2. Gottlieb A
    . Evaluation and management of psoriasis: an internist’s guide. Med Clin North Am 2009;93(6):1291-303.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Menter A,
    2. Gottlieb A,
    3. Feldman SR,
    4. Van Voorhees AS,
    5. Leonardi CL,
    6. Gordon KB,
    7. et al
    . Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol 2008;58(5):826-50.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Feldman SR,
    2. Fleischer AB Jr.,
    3. Cooper JZ
    . New topical treatments change the pattern of treatment of psoriasis: dermatologists remain the primary providers of this care. Int J Dermatol 2000;39(1):41-4.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Horn EJ,
    2. Fox KM,
    3. Patel V,
    4. Chiou CF,
    5. Dann F,
    6. Lebwohl M
    . Are patients with psoriasis undertreated? Results of National Psoriasis Foundation survey. J Am Acad Dermatol 2007;57(6):957-62. Epub 2007 Aug 13.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Mease P
    . Management of psoriatic arthritis: the therapeutic interface between rheumatology and dermatology. Curr Rheumatol Rep 2006;8(5):348-54.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Mease PJ,
    2. Armstrong AW
    . Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis. Drugs 2014;74(4):423-41.
    OpenUrl
  9. 9.↵
    1. Gladman DD
    . Psoriatic arthritis from Wright’s era until today. J Rheum Suppl 2009;(83):4-8.
  10. 10.↵
    1. Kane D,
    2. Stafford L,
    3. Bresnihan B,
    4. FitzGerald O
    . A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. Rheumatology (Oxford) 2003;42(12):1460-8. Epub 2003 Oct 1.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Haroon M,
    2. Kirby B,
    3. FitzGerald O
    . High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires. Ann Rheum Dis 2013;72(5):736-40. Epub 2012 Jun 23.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Wilson FC,
    2. Icen M,
    3. Crowson CS,
    4. McEvoy MT,
    5. Gabriel SE,
    6. Kremers HM
    . Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study. Arthritis Rheum 2009;61(2):233-9. Erratum in: Arthritis Rheum 2010;62(4):574.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Qureshi AA,
    2. Choi HK,
    3. Setty AR,
    4. Curhan JC
    . Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol 2009;145(4):379-82.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Prodanovich S,
    2. Kirsner RS,
    3. Kravetz JD,
    4. Ma F,
    5. Martinez L,
    6. Federman DG
    . Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch Dermatol 2009;145(6):700-3.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Gelfand JM,
    2. Yeung H
    . Metabolic syndrome in patients with psoriatic disease. J Rheumatol Suppl 2012;89:24-8.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Gelfand JM,
    2. Berlin J,
    3. Van Voorhees A,
    4. Margolis DJ
    . Lymphoma rates are low but increased in patients with psoriasis: results from a population-based cohort study in the United Kingdom. Arch Dermatol 2003;139(11):1425-9.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Russo PA,
    2. Ilchef R,
    3. Cooper AJ
    . Psychiatric morbidity in psoriasis: a review. Australas J Dermatol 2004;45(3):155-9.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Menter A,
    2. Korman NJ,
    3. Elmets CA,
    4. Feldman SR,
    5. Gelfand JM,
    6. Gordon KB,
    7. et al
    . Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad Dermatol 2009;60(4):643-59. Epub 2009 Feb 13.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Mason AR,
    2. Mason J,
    3. Cork M,
    4. Dooley G,
    5. Edwards G
    . Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev 2009;(2):CD005028.
  20. 20.↵
    1. Ashcroft DM,
    2. Po AL,
    3. Williams HC,
    4. Griffiths CE
    . Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis. BMJ 2000;320(7240):963-7.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Kragballe K,
    2. Giertsen BT,
    3. De Hoop D,
    4. Karlsmark T,
    5. van de Kerkhof PC,
    6. Larkö O,
    7. et al
    . Double blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991;337(8735):193-6.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Scott LJ,
    2. Dunn CJ,
    3. Goa KL
    . Calcipotriol ointment: a review of its use in the management of psoriasis. Am J Clin Dermatol 2001;2(2):95-120.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Kragballe K,
    2. van de Kerkhof PC
    . Consistency of data in six phase III clinical studies of a two-compound product containing calcipotriol and betamethasone dipropionate ointment for the treatment of psoriasis. J Eur Acad Dermatol Venereol 2006;20(1):39-44.
    OpenUrlPubMed
  24. 24.↵
    1. Menter A,
    2. Korman NJ,
    3. Elmets CA,
    4. Feldman SR,
    5. Gelfand JM,
    6. Gordon KB,
    7. et al
    . Guidelines of care for the management of psoriasis and psoriatic arthritis: section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 2010;62(1):114-35.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Weischer M,
    2. Blum A,
    3. Eberhard F,
    4. Röcken M,
    5. Berneburg M
    . No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB phototherapy: a first retrospective study. Acta Derm Venereol 2004;84(5):370-4.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Lebwohl M,
    2. Drake L,
    3. Menter A,
    4. Koo J,
    5. Gottlieb AB,
    6. Zanolli M,
    7. et al
    . Consensus conference: acitretin in combination with UVB or PUVA in the treatment of psoriasis. J Am Acad Dermatol 2001;45(4):544-53.
    OpenUrlCrossRefPubMed
  27. 27.
    1. Roenigk HH Jr.
    . Acitretin combination therapy. J Am Acad Dermatol 1999;41(3 Pt 2):S18-21.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Koo J
    . Systemic sequential therapy of psoriasis: a new paradigm for improved therapeutic results. J Am Acad Dermatol 1999;41(3 Pt 2):S25-8.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Menter A,
    2. Korman NJ,
    3. Elmets CA,
    4. Feldman SR,
    5. Gelfand JM,
    6. Gordon KB,
    7. et al
    . Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. J Am Acad Dermatol 2009;61(3):451-85.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Saurat JH,
    2. Stingl G,
    3. Dubertret L,
    4. Papp K,
    5. Langley RG,
    6. Ortonne JP,
    7. et al
    . Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION). Br J Dermatol 2008;158(3):558-66. Epub 2007 Nov 28.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Malatjalian DA,
    2. Ross JB,
    3. Williams CN,
    4. Colwell SJ,
    5. Eastwood BJ
    . Methotrexate hepatotoxicity in psoriatics: report of 104 patients from Nova Scotia, with analysis of risks from obesity, diabetes and alcohol consumption during long term follow-up. Can J Gastroenterol 1996;10(6):369-75.
    OpenUrlPubMed
  32. 32.↵
    1. Mahrle G,
    2. Schulze HJ,
    3. Brautigam M,
    4. Mischer P,
    5. Schopf R,
    6. Jung EG,
    7. et al
    . Anti-inflammatory efficacy of low-dose cyclosporin A in psoriatic arthritis: a prospective multicenter study. Br J Dermatol 1996;135:752-7.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Salvarani C,
    2. Macchioni P,
    3. Olivieri I,
    4. Marchesoni A,
    5. Cutolo M,
    6. Ferraccioli G,
    7. et al
    . A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. J Rheumatol 2001;28:2274-82.
    OpenUrlAbstract/FREE Full Text
  34. 34.↵
    1. Ho VC,
    2. Griffiths CE,
    3. Albrecht G,
    4. Vanaclocha F,
    5. León-Dorantes G,
    6. Atakan N,
    7. et al
    . Intermittent short courses of cyclosporin (Neoral(R)) for psoriasis unresponsive to topical therapy: a 1-year multicentre, randomized study. The PISCES Study Group. Br J Dermatol 1999;141(2):283-91.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Menter A,
    2. Korman NJ,
    3. Elmets CA,
    4. Feldman SR,
    5. Gelfand JM,
    6. Gordon KB
    . Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J Am Acad Dermatol 2011;65(1):137-74. Epub 2011 Feb 8.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Lin VW,
    2. Ringold S,
    3. Devine EB
    . Comparison of ustekinumab with other biological agents for the treatment of moderate to severe plaque psoriasis: a Bayesian network meta-analysis. Arch Dermatol 2012;148(12):1403-10.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Dommasch Ed,
    2. Abuabara K,
    3. Shin DB,
    4. Nguyen J,
    5. Troxel AB,
    6. Gelfand JM
    . The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: a systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol 2011;64(6):1035-50. Epub 2011 Feb 18.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Kim WB,
    2. Marinas JE,
    3. Qiang J,
    4. Shahbaz A,
    5. Greaves S,
    6. Yeung J
    . Adverse events resulting in withdrawal of biologic therapy for psoriasis in real-world clinical practice: a Canadian multicenter retrospective study. J Am Acad Dermatol 2015;73(2):237-41. Epub 2015 May 28.
    OpenUrl
PreviousNext
Back to top

In this issue

Canadian Family Physician: 63 (4)
Canadian Family Physician
Vol. 63, Issue 4
1 Apr 2017
  • Table of Contents
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on The College of Family Physicians of Canada.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Diagnosis and management of psoriasis
(Your Name) has sent you a message from The College of Family Physicians of Canada
(Your Name) thought you would like to see the The College of Family Physicians of Canada web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Diagnosis and management of psoriasis
Whan B. Kim, Dana Jerome, Jensen Yeung
Canadian Family Physician Apr 2017, 63 (4) 278-285;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Diagnosis and management of psoriasis
Whan B. Kim, Dana Jerome, Jensen Yeung
Canadian Family Physician Apr 2017, 63 (4) 278-285;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Quality of evidence
    • Main message
    • Conclusion
    • Notes
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF

Related Articles

  • Diagnostic et prise en charge du psoriasis
  • PubMed
  • Google Scholar

Cited By...

  • PLGA-Soya Lecithin Based Hybrid Nanocomposite for Targeted Topical Delivery of Resveratrol in Psoriasis Management
  • Efficacy and Safety of Cannabis Transdermal Patch for Alleviating Psoriasis Symptoms: Protocol for a Randomized Controlled Trial (CanPatch)
  • RNA sequencing of a large number of psoriatic patients identifies 131 novel miRNAs and 11 miRNAs associated with disease severity
  • Glycoconjugation as a Promising Treatment Strategy for Psoriasis
  • Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression
  • Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression
  • Google Scholar

More in this TOC Section

Practice

  • Effectiveness of dermoscopy in skin cancer diagnosis
  • Spontaneous pneumothorax in children
  • Is 45 the new 50 in colorectal cancer screening?
Show more Practice

Clinical Review

  • Top studies of 2024 relevant to primary care
  • Approach to steatotic liver disease in the office
  • Foreskin care
Show more Clinical Review

Similar Articles

Navigate

  • Home
  • Current Issue
  • Archive
  • Collections - English
  • Collections - Française

For Authors

  • Authors and Reviewers
  • Submit a Manuscript
  • Permissions
  • Terms of Use

General Information

  • About CFP
  • About the CFPC
  • Advertisers
  • Careers & Locums
  • Editorial Advisory Board
  • Subscribers

Journal Services

  • Email Alerts
  • Twitter
  • LinkedIn
  • Instagram
  • RSS Feeds

Copyright © 2025 by The College of Family Physicians of Canada

Powered by HighWire